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Gene Review

CT45A1  -  cancer/testis antigen family 45, member A1

Homo sapiens

Synonyms: CT45, CT45-1, CT45.1, Cancer/testis antigen 45-1, Cancer/testis antigen 45A1, ...
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Disease relevance of CT45-1


High impact information on CT45-1

  • Demethylation of CT45-negative HeLa cells and stimulated peripheral blood lymphocytes induced CT45 expression [2].
  • RESULTS: Immunopurification of the 25/22-kDa antigen and sequencing revealed a peptide of 14 amino acids corresponding to the gene product of the newly described gene family MGC27005, located on chromosome Xq26.3, now termed CT45 [2].
  • CT45 is significantly phosphorylated and down-regulated during mitosis [2].

Analytical, diagnostic and therapeutic context of CT45-1

  • The mean regurgitant orifice area at CT-45 mm(2) +/- 34 (range, 10-148 mm(2))-correlated significantly with the results at transesophageal echocardiography (r = 0.807, P < .001) and ventriculography (r = 0.922, P < .001) [3].


  1. Identification of cancer/testis-antigen genes by massively parallel signature sequencing. Chen, Y.T., Scanlan, M.J., Venditti, C.A., Chua, R., Theiler, G., Stevenson, B.J., Iseli, C., Gure, A.O., Vasicek, T., Strausberg, R.L., Jongeneel, C.V., Old, L.J., Simpson, A.J. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  2. Characterization and expression of CT45 in Hodgkin's lymphoma. Heidebrecht, H.J., Claviez, A., Kruse, M.L., Pollmann, M., Buck, F., Harder, S., Tiemann, M., Dörffel, W., Parwaresch, R. Clin. Cancer Res. (2006) [Pubmed]
  3. Mitral regurgitation: quantification with 16-detector row CT--initial experience. Alkadhi, H., Wildermuth, S., Bettex, D.A., Plass, A., Baumert, B., Leschka, S., Desbiolles, L.M., Marincek, B., Boehm, T. Radiology. (2006) [Pubmed]
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