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Gene Review

SNTG1  -  syntrophin, gamma 1

Homo sapiens

Synonyms: G1SYN, Gamma-1-syntrophin, SYN4, Syntrophin-4
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Disease relevance of SNTG1

  • SNTG1, the gene encoding gamma1-syntrophin: a candidate gene for idiopathic scoliosis [1].

High impact information on SNTG1

  • We found that DGK-zeta recruits gamma 1-syntrophin into the nucleus and that the PDZ-binding motif is required [2].
  • Moreover, coimmunoprecipitation and pull-down experiments from brain extracts and cells suggest that DGK-zeta, gamma 1-syntrophin, and dystrophin form a ternary complex [2].
  • Mutational analysis of SNTG1 exons in 152 sporadic IS patients has revealed a 6-bp deletion in exon 10 of SNTG1 in one patient and a 2-bp insertion/deletion mutation occurring in a polypyrimidine tract of intronic sequence 20 bases upstream of the SNTG1 exon 5 splice site in two patients [1].
  • The F line had higher SYN 2 (ED 14, 18, 20, 22), SYN 3 (ED 22), and SYN 4 (ED 22) expression than the RBC2 line [3].
  • The SYN 2 and SYN 4 expression exhibited a similar pattern during embryonic p. major muscle development, which remained constant from ED 14 to ED 22 and declined sharply from ED 22 to ED 24 to a very low level [3].

Anatomical context of SNTG1


Regulatory relationships of SNTG1

  • Collectively, our results suggest that gamma 1-syntrophin participates in regulating the subcellular localization of DGK-zeta to ensure correct termination of diacylglycerol signaling [2].

Other interactions of SNTG1

  • Both SYN 3 and SYN 4 expression stayed almost constant through both the proliferation and differentiation stages [3].


  1. SNTG1, the gene encoding gamma1-syntrophin: a candidate gene for idiopathic scoliosis. Bashiardes, S., Veile, R., Allen, M., Wise, C.A., Dobbs, M., Morcuende, J.A., Szappanos, L., Herring, J.A., Bowcock, A.M., Lovett, M. Hum. Genet. (2004) [Pubmed]
  2. Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions. Hogan, A., Shepherd, L., Chabot, J., Quenneville, S., Prescott, S.M., Topham, M.K., Gee, S.H. J. Biol. Chem. (2001) [Pubmed]
  3. Differential expression of membrane-associated heparan sulfate proteoglycans in the skeletal muscle of turkeys with different growth rates. Liu, C., McFarland, D.C., Nestor, K.E., Velleman, S.G. Poult. Sci. (2006) [Pubmed]
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