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Gene Review

SYN2  -  synapsin II

Homo sapiens

Synonyms: SYNII, SYNIIa, SYNIIb, Synapsin II, Synapsin-2
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Disease relevance of SYN2


Psychiatry related information on SYN2


High impact information on SYN2


Biological context of SYN2


Anatomical context of SYN2


Associations of SYN2 with chemical compounds


Other interactions of SYN2


Analytical, diagnostic and therapeutic context of SYN2

  • We recently reported positive association of synapsin II with schizophrenia in a case-control study (Chen et al. 2004) [5].
  • RESULTS: Although there was no significant difference in the genotypic distributions and allelic frequencies of either SYN2 or CPLX2 polymorphisms between the schizophrenia and control groups, the two-way haplotype analyses revealed significant associations with the disease (P < 0.05 after Bonferroni correction) [9].


  1. The human synapsin II gene promoter. Possible role for the transcription factor zif268/egr-1, polyoma enhancer activator 3, and AP2. Petersohn, D., Schoch, S., Brinkmann, D.R., Thiel, G. J. Biol. Chem. (1995) [Pubmed]
  2. Synapsin IIa bundles actin filaments. Chilcote, T.J., Siow, Y.L., Schaeffer, E., Greengard, P., Thiel, G. J. Neurochem. (1994) [Pubmed]
  3. Altered expression of a-type but not b-type synapsin isoform in the brain of patients at high risk for Alzheimer's disease assessed by DNA microarray technique. Ho, L., Guo, Y., Spielman, L., Petrescu, O., Haroutunian, V., Purohit, D., Czernik, A., Yemul, S., Aisen, P.S., Mohs, R., Pasinetti, G.M. Neurosci. Lett. (2001) [Pubmed]
  4. Molecular characterization of schizophrenia viewed by microarray analysis of gene expression in prefrontal cortex. Mirnics, K., Middleton, F.A., Marquez, A., Lewis, D.A., Levitt, P. Neuron (2000) [Pubmed]
  5. Family-based association study of synapsin II and schizophrenia. Chen, Q., He, G., Qin, W., Chen, Q.Y., Zhao, X.Z., Duan, S.W., Liu, X.M., Feng, G.Y., Xu, Y.F., St Clair, D., Li, M., Wang, J.H., Xing, Y.L., Shi, J.G., He, L. Am. J. Hum. Genet. (2004) [Pubmed]
  6. Synapsin I, synapsin II, and synaptophysin: marker proteins of synaptic vesicles. Thiel, G. Brain Pathol. (1993) [Pubmed]
  7. The synapsins and the regulation of synaptic function. Bähler, M., Benfenati, F., Valtorta, F., Greengard, P. Bioessays (1990) [Pubmed]
  8. Positive association between synapsin II and schizophrenia. Chen, Q., He, G., Wang, X.Y., Chen, Q.Y., Liu, X.M., Gu, Z.Z., Liu, J., Li, K.Q., Wang, S.J., Zhu, S.M., Feng, G.Y., He, L. Biol. Psychiatry (2004) [Pubmed]
  9. Association study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia. Lee, H.J., Song, J.Y., Kim, J.W., Jin, S.Y., Hong, M.S., Park, J.K., Chung, J.H., Shibata, H., Fukumaki, Y. Behavioral and brain functions [electronic resource] : BBF. (2005) [Pubmed]
  10. Differential expression of membrane-associated heparan sulfate proteoglycans in the skeletal muscle of turkeys with different growth rates. Liu, C., McFarland, D.C., Nestor, K.E., Velleman, S.G. Poult. Sci. (2006) [Pubmed]
  11. A quantitative study on the expression of synapsin II and N-ethylmaleimide-sensitive fusion protein in schizophrenic patients. Imai, C., Sugai, T., Iritani, S., Niizato, K., Nakamura, R., Makifuchi, T., Kakita, A., Takahashi, H., Nawa, H. Neurosci. Lett. (2001) [Pubmed]
  12. Proteomic analysis of rat hippocampus and frontal cortex after chronic treatment with fluoxetine or putative novel antidepressants: CRF1 and NK1 receptor antagonists. Carboni, L., Vighini, M., Piubelli, C., Castelletti, L., Milli, A., Domenici, E. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. (2006) [Pubmed]
  13. Invertebrate tissue inhibitor of metalloproteinase: structure and nested gene organization within the synapsin locus is conserved from Drosophila to human. Pohar, N., Godenschwege, T.A., Buchner, E. Genomics (1999) [Pubmed]
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