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Gene Review

DNAJC10  -  DnaJ (Hsp40) homolog, subfamily C, member 10

Homo sapiens

Synonyms: DnaJ homolog subfamily C member 10, ER-resident protein ERdj5, ERDJ5, ERdj5, Endoplasmic reticulum DNA J domain-containing protein 5, ...
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Disease relevance of DNAJC10

  • These results demonstrate that ERdj5 decreases neuroblastoma cell survival by down-regulating the UPR, raising the possibility that this protein could be a target for anti-tumor approaches [1].

High impact information on DNAJC10

  • Its transcription is induced during ER stress, suggesting potential roles for ERdj5 in protein folding and translocation across the ER membrane [2].
  • A computational prediction that JPDI is an ER-resident luminal protein was experimentally supported by immunofluorescent staining of epitope-tagged JPDI-expressing cells together with glycosylation and protease protection studies of this protein [3].

Analytical, diagnostic and therapeutic context of DNAJC10

  • As examined by Northern blotting, the expression of JPDI was essentially ubiquitous in tissues and almost independent of ER stress [3].


  1. ERdj5 sensitizes neuroblastoma cells to endoplasmic reticulum stress-induced apoptosis. Thomas, C.G., Spyrou, G. J. Biol. Chem. (2009) [Pubmed]
  2. ERdj5, an endoplasmic reticulum (ER)-resident protein containing DnaJ and thioredoxin domains, is expressed in secretory cells or following ER stress. Cunnea, P.M., Miranda-Vizuete, A., Bertoli, G., Simmen, T., Damdimopoulos, A.E., Hermann, S., Leinonen, S., Huikko, M.P., Gustafsson, J.A., Sitia, R., Spyrou, G. J. Biol. Chem. (2003) [Pubmed]
  3. JPDI, a novel endoplasmic reticulum-resident protein containing both a BiP-interacting J-domain and thioredoxin-like motifs. Hosoda, A., Kimata, Y., Tsuru, A., Kohno, K. J. Biol. Chem. (2003) [Pubmed]
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