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Gene Review

LRRN3  -  leucine rich repeat neuronal 3

Homo sapiens

Synonyms: FIGLER5, FLJ11129, Leucine-rich repeat neuronal protein 3, NLRR-3, NLRR3, ...
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Disease relevance of LRRN3

  • Rat neuronal leucine-rich repeat protein-3 (rNLRR-3) gene was isolated and cloned from fibrosarcoma cells overexpressing c-Ha-ras [1].

High impact information on LRRN3

  • Most remarkably, in primary NBLs, hNLRR-1 is significantly expressed at high levels in unfavorable subsets as compared to favorable ones, whereas the expression pattern of hNLRR-3 and hNLRR-5 is the opposite [2].
  • Rat neuronal leucine-rich repeat protein-3: cloning and regulation of the gene expression [1].
  • CONCLUSIONS: NRCAM, LRRN3, KIAA0716 are unlikely to be involved in autism [3].

Anatomical context of LRRN3


  1. Rat neuronal leucine-rich repeat protein-3: cloning and regulation of the gene expression. Fukamachi, K., Matsuoka, Y., Kitanaka, C., Kuchino, Y., Tsuda, H. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
  2. Identification of novel human neuronal leucine-rich repeat (hNLRR) family genes and inverse association of expression of Nbla10449/hNLRR-1 and Nbla10677/hNLRR-3 with the prognosis of primary neuroblastomas. Hamano, S., Ohira, M., Isogai, E., Nakada, K., Nakagawara, A. Int. J. Oncol. (2004) [Pubmed]
  3. Examination of NRCAM, LRRN3, KIAA0716, and LAMB1 as autism candidate genes. Hutcheson, H.B., Olson, L.M., Bradford, Y., Folstein, S.E., Santangelo, S.L., Sutcliffe, J.S., Haines, J.L. BMC Med. Genet. (2004) [Pubmed]
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