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Gene Review:

LRRN1 - leucine rich repeat neuronal 1

Homo sapiens

Synonyms: FIGLER3, KIAA1497, Leucine-rich repeat neuronal protein 1, NLRR-1, Nbla10449, ...

Hamano, S. et al., Carim-Todd, L. et al.

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High impact information on LRRN1

LRRN6A encodes a transmembrane leucine-rich repeat protein, LERN1 (leucine-rich repeat neuronal protein 1), with similarity to proteins involved in axonal guidance and migration, nervous system development and regeneration processes [1].
LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex [1].
Most remarkably, in primary NBLs, hNLRR-1 is significantly expressed at high levels in unfavorable subsets as compared to favorable ones, whereas the expression pattern of hNLRR-3 and hNLRR-5 is the opposite [2].
Our present study shows that hNLRR mRNAs are preferentially expressed in nervous system and/or adrenal gland [2].
In cancer cell lines, hNLRR-1, hNLRR-3 and hNLRR-5 are expressed at high levels in the neural crest-derived cells [2].

References

LRRN6A/LERN1 (leucine-rich repeat neuronal protein 1), a novel gene with enriched expression in limbic system and neocortex. Carim-Todd, L., Escarceller, M., Estivill, X., Sumoy, L. Eur. J. Neurosci. (2003) [Pubmed]
Identification of novel human neuronal leucine-rich repeat (hNLRR) family genes and inverse association of expression of Nbla10449/hNLRR-1 and Nbla10677/hNLRR-3 with the prognosis of primary neuroblastomas. Hamano, S., Ohira, M., Isogai, E., Nakada, K., Nakagawara, A. Int. J. Oncol. (2004) [Pubmed]

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LRRN1	Bos taurus
LRRN1	Canis lupus familiaris
lrrn1	Danio rerio
LRRN1	Gallus gallus
LRRN1	Macaca mulatta
Lrrn1	Mus musculus
LRRN1	Pan troglodytes
Lrrn1	Rattus norvegicus
LOC100492182	Xenopus (Silurana) tropicalis

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