Gene Review:
NRCAM - neuronal cell adhesion molecule
Homo sapiens
Synonyms:
Bravo, KIAA0343, Neuronal cell adhesion molecule, Neuronal surface protein Bravo, Ng-CAM-related, ...
Hutcheson,
Olson,
Bradford,
Folstein,
Santangelo,
Sutcliffe,
Haines,
Faivre-Sarrailh,
Falk,
Pollerberg,
Schachner,
Rougon,
Meese,
Hess,
Raisali,
Hajiloo,
Hamidi,
Aslani,
Grumet,
Lane,
Chen,
Yamakawa,
Vielmetter,
Korenberg,
Dreyer,
Petek,
Windpassinger,
Vincent,
Cheung,
Boright,
Scherer,
Kroisel,
Wagner,
Sehgal,
Boynton,
Young,
Vermeulen,
Yonemura,
Kohler,
Aldape,
Simrell,
Murphy,
Lafon,
Zacharias,
Nörenberg,
Rathjen,
- Nr-CAM is a target gene of the beta-catenin/LEF-1 pathway in melanoma and colon cancer and its expression enhances motility and confers tumorigenesis. Conacci-Sorrell, M.E., Ben-Yedidia, T., Shtutman, M., Feinstein, E., Einat, P., Ben-Ze'ev, A. Genes Dev. (2002)
- Targeted ablation of NrCAM or ankyrin-B results in disorganized lens fibers leading to cataract formation. Moré, M.I., Kirsch, F.P., Rathjen, F.G. J. Cell Biol. (2001)
- The shed ectodomain of Nr-CAM stimulates cell proliferation and motility, and confers cell transformation. Conacci-Sorrell, M., Kaplan, A., Raveh, S., Gavert, N., Sakurai, T., Ben-Ze'ev, A. Cancer Res. (2005)
- Rabies virus receptors. Lafon, M. J. Neurovirol. (2005)
- Interocular suppression is gated by interocular feature matching. Meese, T.S., Hess, R.F. Vision Res. (2005)
- Spectrum and detection rate of L1CAM mutations in isolated and familial cases with clinically suspected L1-disease. Finckh, U., Schröder, J., Ressler, B., Veske, A., Gal, A. Am. J. Med. Genet. (2000)
- Association analysis of the NrCAM gene in autism and in subsets of families with severe obsessive-compulsive or self-stimulatory behaviors. Sakurai, T., Ramoz, N., Reichert, J.G., Corwin, T.E., Kryzak, L., Smith, C.J., Silverman, J.M., Hollander, E., Buxbaum, J.D. Psychiatr. Genet. (2006)
- Under the eye of Nr-CAM. Nguyen-Ba-Charvet, K.T., Chédotal, A. Neuron (2006)
- Interference with axonin-1 and NrCAM interactions unmasks a floor-plate activity inhibitory for commissural axons. Stoeckli, E.T., Sonderegger, P., Pollerberg, G.E., Landmesser, L.T. Neuron (1997)
- Cloning, expression, and characterization of sialic acid synthases. Hao, J., Balagurumoorthy, P., Sarilla, S., Sundaramoorthy, M. Biochem. Biophys. Res. Commun. (2005)
- Survival of pathogenic bacteria in pesticide solutions and on treated tomato plants. Guan, T.T., Blank, G., Holley, R.A. J. Food Prot. (2005)
- The complete sequence of the human locus for NgCAM-related cell adhesion molecule reveals a novel alternative exon in chick and man and conserved genomic organization for the L1 subfamily. Dry, K., Kenwrick, S., Rosenthal, A., Platzer, M. Gene (2001)
- Nr-CAM: a cell adhesion molecule with ligand and receptor functions. Grumet, M. Cell Tissue Res. (1997)
- Alternative splicing of human NrCAM in neural and nonneural tissues. Wang, B., Williams, H., Du, J.S., Terrett, J., Kenwrick, S. Mol. Cell. Neurosci. (1998)
- Characterization of a highly conserved human homolog to the chicken neural cell surface protein Bravo/Nr-CAM that maps to chromosome band 7q31. Lane, R.P., Chen, X.N., Yamakawa, K., Vielmetter, J., Korenberg, J.R., Dreyer, W.J. Genomics (1996)
- Analysis of interactions of the adhesion molecule TAG-1 and its domains with other immunoglobulin superfamily members. Pavlou, O., Theodorakis, K., Falk, J., Kutsche, M., Schachner, M., Faivre-Sarrailh, C., Karagogeos, D. Mol. Cell. Neurosci. (2002)
- Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM. Aitkenhead, M., Wang, S.J., Nakatsu, M.N., Mestas, J., Heard, C., Hughes, C.C. Microvasc. Res. (2002)
- Induction of neurite outgrowth through contactin and Nr-CAM by extracellular regions of glial receptor tyrosine phosphatase beta. Sakurai, T., Lustig, M., Nativ, M., Hemperly, J.J., Schlessinger, J., Peles, E., Grumet, M. J. Cell Biol. (1997)
- Analysis of neutron and gamma-ray streaming along the maze of NRCAM thallium production target room. Raisali, G., Hajiloo, N., Hamidi, S., Aslani, G. Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine. (2006)
- L1-associated diseases: clinical geneticists divide, molecular geneticists unite. Fransen, E., Van Camp, G., Vits, L., Willems, P.J. Hum. Mol. Genet. (1997)
- Complementary patterns of gene expression by human oligodendrocyte progenitors and their environment predict determinants of progenitor maintenance and differentiation. Sim, F.J., Lang, J.K., Waldau, B., Roy, N.S., Schwartz, T.E., Pilcher, W.H., Chandross, K.J., Natesan, S., Merrill, J.E., Goldmanm, S.A. Ann. Neurol. (2006)
- Activation of serum response factor by RhoA is mediated by the nuclear factor-kappaB and C/EBP transcription factors. Montaner, S., Perona, R., Saniger, L., Lacal, J.C. J. Biol. Chem. (1999)
- Functional cooperation of beta1-integrins and members of the Ig superfamily in neurite outgrowth induction. Treubert, U., Brümmendorf, T. J. Neurosci. (1998)
- Functional interactions of the immunoglobulin superfamily member F11 are differentially regulated by the extracellular matrix proteins tenascin-R and tenascin-C. Zacharias, U., Nörenberg, U., Rathjen, F.G. J. Biol. Chem. (1999)
- Disruption of a novel gene (IMMP2L) by a breakpoint in 7q31 associated with Tourette syndrome. Petek, E., Windpassinger, C., Vincent, J.B., Cheung, J., Boright, A.P., Scherer, S.W., Kroisel, P.M., Wagner, K. Am. J. Hum. Genet. (2001)
- Examination of NRCAM, LRRN3, KIAA0716, and LAMB1 as autism candidate genes. Hutcheson, H.B., Olson, L.M., Bradford, Y., Folstein, S.E., Santangelo, S.L., Sutcliffe, J.S., Haines, J.L. BMC Med. Genet. (2004)
- Mutation screening and association analysis of six candidate genes for autism on chromosome 7q. Bonora, E., Lamb, J.A., Barnby, G., Sykes, N., Moberly, T., Beyer, K.S., Klauck, S.M., Poustka, F., Bacchelli, E., Blasi, F., Maestrini, E., Battaglia, A., Haracopos, D., Pedersen, L., Isager, T., Eriksen, G., Viskum, B., Sorensen, E.U., Brondum-Nielsen, K., Cotterill, R., Engeland, H., Jonge, M., Kemner, C., Steggehuis, K., Scherpenisse, M., Rutter, M., Bolton, P.F., Parr, J.R., Poustka, A., Bailey, A.J., Monaco, A.P. Eur. J. Hum. Genet. (2005)
- Neurofascin interactions play a critical role in clustering sodium channels, ankyrin(G) and betaIV spectrin at peripheral nodes of Ranvier. Koticha, D., Maurel, P., Zanazzi, G., Kane-Goldsmith, N., Basak, S., Babiarz, J., Salzer, J., Grumet, M. Dev. Biol. (2006)
- NrCAM, cerebellar granule cell receptor for the neuronal adhesion molecule F3, displays an actin-dependent mobility in growth cones. Faivre-Sarrailh, C., Falk, J., Pollerberg, E., Schachner, M., Rougon, G. J. Cell. Sci. (1999)
- Changes in the relative proportion of transformation-sensitive polypeptides in giant HeLa cells produced by irradiation with lethal doses of x-rays. Bellatin, J., Bravo, R., Celis, J.E. Proc. Natl. Acad. Sci. U.S.A. (1982)
- Further studies of elevated cerebrospinal fluid neuronal cell adhesion molecule in schizophrenia. van Kammen, D.P., Poltorak, M., Kelley, M.E., Yao, J.K., Gurklis, J.A., Peters, J.L., Hemperly, J.J., Wright, R.D., Freed, W.J. Biol. Psychiatry (1998)
- Cell adhesion molecule Nr-CAM is over-expressed in human brain tumors. Sehgal, A., Boynton, A.L., Young, R.F., Vermeulen, S.S., Yonemura, K.S., Kohler, E.P., Aldape, H.C., Simrell, C.R., Murphy, G.P. Int. J. Cancer (1998)