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NCAPG2  -  non-SMC condensin II complex, subunit G2

Homo sapiens

Synonyms: CAP-G2, CAPG2, Chromosome-associated protein G2, Condensin-2 complex subunit G2, FLJ20311, ...
 
 
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Disease relevance of NCAPG2

  • MCPH1 and Condensin II interact in vivo, mediated by the CAPG2 subunit of Condensin II binding to a middle domain (residues 376-485) of MCPH1 [1].
 

High impact information on NCAPG2

  • Since MTB is highly expressed in the fetal liver and developing thymus, we predicted that MTB would be required for hematopoiesis and that embryos deficient in MTB would die of anemia [2].
  • In this report, we show that MTB (more than blood), which was initially isolated in a yeast two-hybrid screen for proteins that interact with the basic helix-loop-helix (bHLH) protein stem cell leukemia (SCL), and later identified as the murine homolog of the condensin II subunit CAP-G2, participates in erythroid cell development [3].
  • MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription and promotes erythroid cell differentiation [3].
  • Collectively, we have identified a novel function of MCPH1 to modulate HR repair through Condensin II, and thereby maintain genome integrity [3].
 

Biological context of NCAPG2

  • siRNA-mediated depletion of condensin I- or condensin II-specific subunits in HeLa cells produces a distinct, highly characteristic defect in chromosome morphology [4].
  • Depletion of hCAP-G2 affects the physical rigidity of the chromatid axis [4].
 

Anatomical context of NCAPG2

  • MTB is highly expressed in the fetal liver and developing thymus [3].

References

  1. Microcephalin/MCPH1 associates with the Condensin II complex to function in homologous recombination repair. Wood, J.L., Liang, Y., Li, K., Chen, J. J. Biol. Chem. (2008) [Pubmed]
  2. More than blood, a novel gene required for mammalian postimplantation development. Smith, E.D., Xu, Y., Tomson, B.N., Leung, C.G., Fujiwara, Y., Orkin, S.H., Crispino, J.D. Mol. Cell. Biol. (2004) [Pubmed]
  3. MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription and promotes erythroid cell differentiation. Xu, Y., Leung, C.G., Lee, D.C., Kennedy, B.K., Crispino, J.D. Leukemia (2006) [Pubmed]
  4. Differential contributions of condensin I and condensin II to mitotic chromosome architecture in vertebrate cells. Ono, T., Losada, A., Hirano, M., Myers, M.P., Neuwald, A.F., Hirano, T. Cell. (2003) [Pubmed]
 
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