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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

pitx2  -  paired-like homeodomain 2

Xenopus (Silurana) tropicalis

Synonyms: arp1, brx1, idg2, igds, igds2, ...
 
 
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High impact information on pitx2

  • The experimental manipulation of early embryologic events, resulting in the misexpression of the homeobox transcription factor pitx2, is associated with subsequent defects of laterality in a number of vertebrate systems [1].
  • Right-side injection of Nodal protein, or polyethyleneimine-based gene transfer of Xnr-1 mRNA in the right LPM induces Xnr-1 and pitx2 in the same side and fully (more than 90%) reverses situs of the internal organs [2].

References

  1. Pitx2c attenuation results in cardiac defects and abnormalities of intestinal orientation in developing Xenopus laevis. Dagle, J.M., Sabel, J.L., Littig, J.L., Sutherland, L.B., Kolker, S.J., Weeks, D.L. Dev. Biol. (2003) [Pubmed]
  2. Xenopus nodal related-1 is indispensable only for left-right axis determination. Toyoizumi, R., Ogasawara, T., Takeuchi, S., Mogi, K. Int. J. Dev. Biol. (2005) [Pubmed]
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