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Gene Review

pitx2  -  paired-like homeodomain 2

Xenopus (Silurana) tropicalis

Synonyms: arp1, brx1, idg2, igds, igds2, ...
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High impact information on pitx2

  • The experimental manipulation of early embryologic events, resulting in the misexpression of the homeobox transcription factor pitx2, is associated with subsequent defects of laterality in a number of vertebrate systems [1].
  • Right-side injection of Nodal protein, or polyethyleneimine-based gene transfer of Xnr-1 mRNA in the right LPM induces Xnr-1 and pitx2 in the same side and fully (more than 90%) reverses situs of the internal organs [2].


  1. Pitx2c attenuation results in cardiac defects and abnormalities of intestinal orientation in developing Xenopus laevis. Dagle, J.M., Sabel, J.L., Littig, J.L., Sutherland, L.B., Kolker, S.J., Weeks, D.L. Dev. Biol. (2003) [Pubmed]
  2. Xenopus nodal related-1 is indispensable only for left-right axis determination. Toyoizumi, R., Ogasawara, T., Takeuchi, S., Mogi, K. Int. J. Dev. Biol. (2005) [Pubmed]
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