The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Editor

Share

Personal info

View

Links

  • Homologues
  • NCBI Gene
  • NCBI SNP
  • iHOP resource
  • SNPedia

Table of contents

About

Terms

 

Gene Review: 

PITX2  -  paired-like homeodomain 2

Gallus gallus

 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on PITX2

  • The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals [1].
  • We implanted BMP2 and Noggin-expressing cells into the left lateral plate and paraxial mesoderm and observed a strong upregulation of Nodal and its target genes Pitx2 and Nkx3 [2].
  • We further constructed RCAS retroviral vectors expressing dominant negative Pitx2 isoforms in which the C-terminal transcriptional activation domain was replaced by the repressor domain of the Drosophila Engrailed protein (En(r)) [3].
  • We have examined the differential expression and function of two Pitx2 isoforms (Pitx2a and Pitx2c) that differ in the region 5' to the homeodomain, in early chick embryogenesis [3].
  • Further downstream in this pathway are the left-specific genes nodal, lefty-1, lefty-2 and Pitx2 [1] [3] [4] [5] [4].
 

Other interactions of PITX2

  • Cloning and expression pattern of chicken Pitx2: a new component in the SHH signaling pathway controlling embryonic heart looping [5].

References

  1. The transcription factor Pitx2 mediates situs-specific morphogenesis in response to left-right asymmetric signals. Logan, M., Pagán-Westphal, S.M., Smith, D.M., Paganessi, L., Tabin, C.J. Cell (1998) [Pubmed]
  2. BMP2 is a positive regulator of Nodal signaling during left-right axis formation in the chicken embryo. Schlange, T., Arnold, H.H., Brand, T. Development (2002) [Pubmed]
  3. Differential expression and functional analysis of Pitx2 isoforms in regulation of heart looping in the chick. Yu, X., St Amand, T.R., Wang, S., Li, G., Zhang, Y., Hu, Y.P., Nguyen, L., Qiu, M.S., Chen, Y.P. Development (2001) [Pubmed]
  4. FGF8 functions in the specification of the right body side of the chick. Boettger, T., Wittler, L., Kessel, M. Curr. Biol. (1999) [Pubmed]
  5. Cloning and expression pattern of chicken Pitx2: a new component in the SHH signaling pathway controlling embryonic heart looping. St Amand, T.R., Ra, J., Zhang, Y., Hu, Y., Baber, S.I., Qiu, M., Chen, Y. Biochem. Biophys. Res. Commun. (1998) [Pubmed]
Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg
 
WikiGenes - Universities