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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Pitx2  -  paired-like homeodomain 2

Rattus norvegicus

Synonyms: Homeobox protein PITX2, Paired-like homeodomain transcription factor 2, Pituitary homeobox 2, Pitx-2, Pitx2c, ...
 
 
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High impact information on Pitx2

  • Three different transcripts of the homeodomain gene termed pituitary homeobox (Ptx) 2 (Pitx2/Brx/Rieg/Solurshin/Arp) were cloned from different species encoding proteins belonging to the paired-like family of homeodomain proteins [1].
  • Ptx2 is able to trans-activate via different model promoters in different cell lines [1].
  • The data presented suggest that all variants of Ptx2 are involved in the development and regulation of distinct neuronal cell groups and the pituitary gland [1].
 

Analytical, diagnostic and therapeutic context of Pitx2

References

  1. Analysis of three Ptx2 splice variants on transcriptional activity and differential expression pattern in the brain. Smidt, M.P., Cox, J.J., van Schaick, H.S., Coolen, M., Schepers, J., van der Kleij, A.M., Burbach, J.P. J. Neurochem. (2000) [Pubmed]
  2. Regulated expression of the homeobox gene, rPtx2, in the developing rat. Lindberg, C., Wunderlich, M., Ratliff, J., Dinsmore, J., Jacoby, D.B. Brain Res. Dev. Brain Res. (1998) [Pubmed]
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