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Gene Review

tbpl2  -  TATA box binding protein like 2

Xenopus (Silurana) tropicalis

Synonyms: tbp, tbp2, trf3, xTBPL2
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High impact information on tbp

  • The transcriptional activity of the TFIIIB-TBP fraction can be modulated in vitro by phosphorylation with mitotic kinases and by dephosphorylation with immobilized alkaline phosphatase [1].
  • After this stage, when transcription of the rRNA genes has begun, nucleoli developed and the NORs acquired TBP and pol I [2].
  • The Xenopus laevis selenocysteine tRNA[Ser]Sec gene utilizes the TATA box binding protein (TBP) for its transcription in a manner more like TATA-dependent class II genes than TATA-less class III tRNA genes, even though this gene is transcribed by RNA polymerase III (Pol III) [3].
  • On the basis of these results together with phylogenetical exam-ination, we speculate that tlp diverged from an ancestral tbp gene through a process of gene duplication and point mutations [4].
  • Interestingly, the vertebrate tbp genes were also found to be split by five introns when we focused on the CCDs, and their splicing points were similar to those of tlp [4].

Biological context of tbp

  • These studies provide evidence that common surfaces of TBP may be used in transcription from TATA-dependent promoters of the tRNA[Ser]Sec gene and class II genes [3].


  1. Mitotic repression of RNA polymerase III transcription in vitro mediated by phosphorylation of a TFIIIB component. Gottesfeld, J.M., Wolf, V.J., Dang, T., Forbes, D.J., Hartl, P. Science (1994) [Pubmed]
  2. Association of the nucleolar transcription factor UBF with the transcriptionally inactive rRNA genes of pronuclei and early Xenopus embryos. Bell, P., Mais, C., McStay, B., Scheer, U. J. Cell. Sci. (1997) [Pubmed]
  3. Differential mode of TBP utilization in transcription of the tRNA[Ser]Sec gene and TATA-less class III genes. Park, J.M., Lee, J.Y., Hatfield, D.L., Lee, B.J. Gene (1997) [Pubmed]
  4. Analysis of the chicken TBP-like protein(tlp) gene: evidence for a striking conservation of vertebrate TLPs and for a close relationship between vertebrate tbp and tlp genes. Shimada, M., Ohbayashi, T., Ishida, M., Nakadai, T., Makino, Y., Aoki, T., Kawata, T., Suzuki, T., Matsuda, Y., Tamura, T. Nucleic Acids Res. (1999) [Pubmed]
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