The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

TBP1  -  TATA-box-binding protein 1

Arabidopsis thaliana

Synonyms: TATA binding protein 1, TFIID-1, TRANSCRIPTION FACTOR IID-1
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of TBP1


High impact information on TBP1

  • Crystal structure of TFIID TATA-box binding protein [4].
  • Binding of TFIID to the TATA box initiates the assembly of other general transcription factors as well as RNA polymerase II at the promoter resulting in a preinitiation complex capable of accurate transcription initiation in vitro [5].
  • The TATA-binding protein TBP appears to be essential for all transcription in eukaryotic cell nuclei, which suggests that its function was established early in evolution [6].
  • The expressed tRNA(Trp) genes contain no highly conserved 5' flanking sequences; however, these sequences are distinctly AT rich, contain several possible TATA elements, and are bound in vitro by recombinant plant TATA binding protein [7].
  • In addition, we show that the maize TBP products, unlike animal TBPs, are functionally interchangeable with yeast TBP for conferring yeast cell viability [8].

Chemical compound and disease context of TBP1

  • The hydroxyl radical footprint of the TATA-binding protein (TBP) bound to the high-affinity sequence TATAAAAG of the adenovirus 2 major late promoter has been quantitatively compared to a 2 ns molecular dynamics simulation of the complex in aqueous solution at room temperature using the CHARMM23 potential [9].

Biological context of TBP1

  • The carboxy-terminal portion of TBP is a unique DNA-binding motif/protein fold, adopting a highly symmetric alpha/beta structure that resembles a molecular saddle with two stirrup-like loops [10].
  • These data suggest that the TBP gene dosage and/or expression level may play an important role in controlling shoot production and plant morphology [11].
  • The cocrystal structure of the C-terminal/core region of human TBP complexed with the TATA element of the adenovirus major late promoter has been determined at 1.9 angstroms resolution [12].
  • We have generated a TATA-binding-defective TFIID complex containing an amino acid substitution in the DNA-binding surface of its TBP subunit [13].
  • Arabidopsis HAF2 gene encoding TATA-binding protein (TBP)-associated factor TAF1, is required to integrate light signals to regulate gene expression and growth [14].

Associations of TBP1 with chemical compounds

  • TBP interacts with guanine bases flanking the TATA element in the simulations of the complex; these interactions may explain the preference for guanine observed at these DNA positions [15].

Other interactions of TBP1


Analytical, diagnostic and therapeutic context of TBP1


  1. TATA element recognition by the TATA box-binding protein has been conserved throughout evolution. Patikoglou, G.A., Kim, J.L., Sun, L., Yang, S.H., Kodadek, T., Burley, S.K. Genes Dev. (1999) [Pubmed]
  2. Hepatitis B virus transactivator protein X interacts with the TATA-binding protein. Qadri, I., Maguire, H.F., Siddiqui, A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  3. The gene for the TATA box-binding protein of Onchocerca volvulus. Li, S., Donelson, J.E. Mol. Biochem. Parasitol. (1993) [Pubmed]
  4. Crystal structure of TFIID TATA-box binding protein. Nikolov, D.B., Hu, S.H., Lin, J., Gasch, A., Hoffmann, A., Horikoshi, M., Chua, N.H., Roeder, R.G., Burley, S.K. Nature (1992) [Pubmed]
  5. Arabidopsis thaliana contains two genes for TFIID. Gasch, A., Hoffmann, A., Horikoshi, M., Roeder, R.G., Chua, N.H. Nature (1990) [Pubmed]
  6. The TATA-binding protein: a general transcription factor in eukaryotes and archaebacteria. Rowlands, T., Baumann, P., Jackson, S.P. Science (1994) [Pubmed]
  7. Analysis of the role of 5' and 3' flanking sequence elements upon in vivo expression of the plant tRNATrp genes. Ulmasov, B., Folk, W. Plant Cell (1995) [Pubmed]
  8. Expression of the two maize TATA binding protein genes and function of the encoded TBP proteins by complementation in yeast. Vogel, J.M., Roth, B., Cigan, M., Freeling, M. Plant Cell (1993) [Pubmed]
  9. A detailed interpretation of OH radical footprints in a TBP-DNA complex reveals the role of dynamics in the mechanism of sequence-specific binding. Pastor, N., Weinstein, H., Jamison, E., Brenowitz, M. J. Mol. Biol. (2000) [Pubmed]
  10. 2.1 A resolution refined structure of a TATA box-binding protein (TBP). Nikolov, D.B., Burley, S.K. Nat. Struct. Biol. (1994) [Pubmed]
  11. Ectopic expression of TATA box-binding protein induces shoot proliferation in Arabidopsis. Li, Y.F., Dubois, F., Zhou, D.X. FEBS Lett. (2001) [Pubmed]
  12. Crystal structure of a human TATA box-binding protein/TATA element complex. Nikolov, D.B., Chen, H., Halay, E.D., Hoffman, A., Roeder, R.G., Burley, S.K. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  13. Core promoter-specific function of a mutant transcription factor TFIID defective in TATA-box binding. Martinez, E., Zhou, Q., L'Etoile, N.D., Oelgeschläger, T., Berk, A.J., Roeder, R.G. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  14. Arabidopsis HAF2 gene encoding TATA-binding protein (TBP)-associated factor TAF1, is required to integrate light signals to regulate gene expression and growth. Bertrand, C., Benhamed, M., Li, Y.F., Ayadi, M., Lemonnier, G., Renou, J.P., Delarue, M., Zhou, D.X. J. Biol. Chem. (2005) [Pubmed]
  15. DNA binding by TATA-box binding protein (TBP): a molecular dynamics computational study. Miaskiewicz, K., Ornstein, R.L. J. Biomol. Struct. Dyn. (1996) [Pubmed]
  16. Interaction between the Arabidopsis thaliana heat shock transcription factor HSF1 and the TATA binding protein TBP. Reindl, A., Schöffl, F. FEBS Lett. (1998) [Pubmed]
  17. The maize Single myb histone 1 gene, Smh1, belongs to a novel gene family and encodes a protein that binds telomere DNA repeats in vitro. Marian, C.O., Bordoli, S.J., Goltz, M., Santarella, R.A., Jackson, L.P., Danilevskaya, O., Beckstette, M., Meeley, R., Bass, H.W. Plant Physiol. (2003) [Pubmed]
WikiGenes - Universities