The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Genes, MHC Class II

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Genes, MHC Class II


High impact information on Genes, MHC Class II

  • In vivo primary skin graft responses to H-Y are controlled by immune response (Ir) genes mapping to the MHC [6].
  • The discovery of Ir gene control of specific immune responses and the role of MHC molecules as presenters of peptide antigens to T cells [7].
  • Since DRB generally affects class II genes, factors involved in this process must play fundamental roles in pol II elongation [8].
  • METHODS: To elucidate the genetic defect in patients with MHC class II deficiency that was not classified genetically, we performed direct complementation assays with the three genes known to regulate the expression of MHC class II genes, CIITA, RFX5, and RFXAP, and the relevant mutations were identified in each patient [9].
  • Mutation of RFXAP, a regulator of MHC class II genes, in primary MHC class II deficiency [9].

Chemical compound and disease context of Genes, MHC Class II


Biological context of Genes, MHC Class II


Anatomical context of Genes, MHC Class II


Associations of Genes, MHC Class II with chemical compounds


Gene context of Genes, MHC Class II


Analytical, diagnostic and therapeutic context of Genes, MHC Class II


  1. Regulation of genes for HLA class II antigens in cell lines from patients with severe combined immunodeficiency. de Préval, C., Hadam, M.R., Mach, B. N. Engl. J. Med. (1988) [Pubmed]
  2. Membrane Ia expression and antigen-presenting accessory cell function of L cells transfected with class II major histocompatibility complex genes. Norcross, M.A., Bentley, D.M., Margulies, D.H., Germain, R.N. J. Exp. Med. (1984) [Pubmed]
  3. Reactivation of a major histocompatibility complex class II gene in mouse plasmacytoma cells and mouse T cells. Chang, C.H., Fodor, W.L., Flavell, R.A. J. Exp. Med. (1992) [Pubmed]
  4. Arginine at positions 13 or 70-71 in pocket 4 of HLA-DRB1 alleles is associated with susceptibility to tuberculoid leprosy. Zerva, L., Cizman, B., Mehra, N.K., Alahari, S.K., Murali, R., Zmijewski, C.M., Kamoun, M., Monos, D.S. J. Exp. Med. (1996) [Pubmed]
  5. In vitro proliferative responses and antibody titers specific to human acetylcholine receptor synthetic peptides in patients with myasthenia gravis and relation to HLA class II genes. Brocke, S., Brautbar, C., Steinman, L., Abramsky, O., Rothbard, J., Neumann, D., Fuchs, S., Mozes, E. J. Clin. Invest. (1988) [Pubmed]
  6. The male-specific histocompatibility antigen, H-Y: a history of transplantation, immune response genes, sex determination and expression cloning. Simpson, E., Scott, D., Chandler, P. Annu. Rev. Immunol. (1997) [Pubmed]
  7. When all is said and done.... Benacerraf, B. Annu. Rev. Immunol. (1991) [Pubmed]
  8. NELF, a multisubunit complex containing RD, cooperates with DSIF to repress RNA polymerase II elongation. Yamaguchi, Y., Takagi, T., Wada, T., Yano, K., Furuya, A., Sugimoto, S., Hasegawa, J., Handa, H. Cell (1999) [Pubmed]
  9. Mutation of RFXAP, a regulator of MHC class II genes, in primary MHC class II deficiency. Villard, J., Lisowska-Grospierre, B., van den Elsen, P., Fischer, A., Reith, W., Mach, B. N. Engl. J. Med. (1997) [Pubmed]
  10. Primarily chronic progressive and relapsing/remitting multiple sclerosis: two immunogenetically distinct disease entities. Olerup, O., Hillert, J., Fredrikson, S., Olsson, T., Kam-Hansen, S., Möller, E., Carlsson, B., Wallin, J. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  11. LPS induces CD40 gene expression through the activation of NF-kappaB and STAT-1alpha in macrophages and microglia. Qin, H., Wilson, C.A., Lee, S.J., Zhao, X., Benveniste, E.N. Blood (2005) [Pubmed]
  12. Suppressive effect of antibodies to immune response gene products on the development of low-dose streptozotocin-induced diabetes. Kiesel, U., Kolb, H. Diabetes (1983) [Pubmed]
  13. Influence of HLA-DR and -DO phenotypes on tuberculin reactive status in pulmonary tuberculosis patients. Selvaraj, P., Reetha, A.M., Uma, H., Xavier, T., Janardhanam, B., Prabhakar, R., Narayanan, P.R. Tuber. Lung Dis. (1996) [Pubmed]
  14. The murine E alpha immune response gene. Mathis, D.J., Benoist, C.O., Williams, V.E., Kanter, M.R., McDevitt, H.O. Cell (1983) [Pubmed]
  15. Congenital immunodeficiency with a regulatory defect in MHC class II gene expression lacks a specific HLA-DR promoter binding protein, RF-X. Reith, W., Satola, S., Sanchez, C.H., Amaldi, I., Lisowska-Grospierre, B., Griscelli, C., Hadam, M.R., Mach, B. Cell (1988) [Pubmed]
  16. Nucleotide sequence of mutant I-A beta bm12 gene is evidence for genetic exchange between mouse immune response genes. McIntyre, K.R., Seidman, J.G. Nature (1984) [Pubmed]
  17. T-cell specificity for H-2 and Ir gene phenotype correlates with the phenotype of thymic antigen-presenting cells. Longo, D.L., Schwartz, R.H. Nature (1980) [Pubmed]
  18. The origin of MHC class II gene polymorphism within the genus Mus. McConnell, T.J., Talbot, W.S., McIndoe, R.A., Wakeland, E.K. Nature (1988) [Pubmed]
  19. cis-acting sequences required for class II gene regulation by interferon gamma and tumor necrosis factor alpha in a murine macrophage cell line. Freund, Y.R., Dedrick, R.L., Jones, P.P. J. Exp. Med. (1990) [Pubmed]
  20. The xid gene controls Ia.W39-associated immune response gene function. Rosenwasser, L.J., Huber, B.T. J. Exp. Med. (1981) [Pubmed]
  21. Interleukin 12 p40 production by barrier epithelial cells during airway inflammation. Walter, M.J., Kajiwara, N., Karanja, P., Castro, M., Holtzman, M.J. J. Exp. Med. (2001) [Pubmed]
  22. Class II transactivator regulates the expression of multiple genes involved in antigen presentation. Chang, C.H., Flavell, R.A. J. Exp. Med. (1995) [Pubmed]
  23. Ir gene function in an I-A subregion mutant B6.C-H-2bm12. Michaelides, M., Sandrin, M., Morgan, G., McKenzie, I.F., Ashman, R., Melvold, R.W. J. Exp. Med. (1981) [Pubmed]
  24. Regions of allelic hypervariability in the murine A alpha immune response gene. Benoist, C.O., Mathis, D.J., Kanter, M.R., Williams, V.E., McDevitt, H.O. Cell (1983) [Pubmed]
  25. Complementation of immune response genes for (T,G)-A-L. Munro, A.J., Taussig, M. Nature (1977) [Pubmed]
  26. Class II transactivator (CIITA) is sufficient for the inducible expression of major histocompatibility complex class II genes. Chang, C.H., Fontes, J.D., Peterlin, M., Flavell, R.A. J. Exp. Med. (1994) [Pubmed]
  27. Complementation of H-2-linked Ir genes in the mouse. Dorf, M.E., Benacerraf, B. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  28. Complementation cloning of an MHC class II transactivator mutated in hereditary MHC class II deficiency (or bare lymphocyte syndrome). Steimle, V., Otten, L.A., Zufferey, M., Mach, B. Cell (1993) [Pubmed]
  29. Dual role of TFIIH in DNA excision repair and in transcription by RNA polymerase II. Drapkin, R., Reardon, J.T., Ansari, A., Huang, J.C., Zawel, L., Ahn, K., Sancar, A., Reinberg, D. Nature (1994) [Pubmed]
  30. A Drosophila IkappaB kinase complex required for Relish cleavage and antibacterial immunity. Silverman, N., Zhou, R., Stöven, S., Pandey, N., Hultmark, D., Maniatis, T. Genes Dev. (2000) [Pubmed]
  31. Coordinate activation of activator protein 1 and inflammatory cytokines in response to Neisseria gonorrhoeae epithelial cell contact involves stress response kinases. Naumann, M., Rudel, T., Wieland, B., Bartsch, C., Meyer, T.F. J. Exp. Med. (1998) [Pubmed]
  32. Genetic analysis of type 1 diabetes using whole genome approaches. Todd, J.A. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  33. A unique sequence of the NZW I-E beta chain and its possible contribution to autoimmunity in the (NZB x NZW)F1 mouse. Schiffenbauer, J., McCarthy, D.M., Nygard, N.R., Woulfe, S.L., Didier, D.K., Schwartz, B.D. J. Exp. Med. (1989) [Pubmed]
  34. Human HLA-DR beta gene hypervariable region homology in the biobreeding BB rat: selection of the diabetic-resistant subline as a rheumatoid arthritis research tool to characterize the immunopathologic response to human type II collagen. Watson, W.C., Thompson, J.P., Terato, K., Cremer, M.A., Kang, A.H. J. Exp. Med. (1990) [Pubmed]
  35. Gene expression profiling in CD34 cells to identify differences between aplastic anemia patients and healthy volunteers. Zeng, W., Chen, G., Kajigaya, S., Nunez, O., Charrow, A., Billings, E.M., Young, N.S. Blood (2004) [Pubmed]
  36. Peptide-induced suppression of collagen-induced arthritis in HLA-DR1 transgenic mice. Myers, L.K., Sakurai, Y., Tang, B., He, X., Rosloniec, E.F., Stuart, J.M., Kang, A.H. Arthritis Rheum. (2002) [Pubmed]
  37. Absence of MHC class II expression distinguishes fetal from adult B lymphopoiesis in mice. Hayakawa, K., Tarlinton, D., Hardy, R.R. J. Immunol. (1994) [Pubmed]
WikiGenes - Universities