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MeSH Review

Genes, MHC Class II

 
 
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Disease relevance of Genes, MHC Class II

 

High impact information on Genes, MHC Class II

  • In vivo primary skin graft responses to H-Y are controlled by immune response (Ir) genes mapping to the MHC [6].
  • The discovery of Ir gene control of specific immune responses and the role of MHC molecules as presenters of peptide antigens to T cells [7].
  • Since DRB generally affects class II genes, factors involved in this process must play fundamental roles in pol II elongation [8].
  • METHODS: To elucidate the genetic defect in patients with MHC class II deficiency that was not classified genetically, we performed direct complementation assays with the three genes known to regulate the expression of MHC class II genes, CIITA, RFX5, and RFXAP, and the relevant mutations were identified in each patient [9].
  • Mutation of RFXAP, a regulator of MHC class II genes, in primary MHC class II deficiency [9].
 

Chemical compound and disease context of Genes, MHC Class II

 

Biological context of Genes, MHC Class II

 

Anatomical context of Genes, MHC Class II

 

Associations of Genes, MHC Class II with chemical compounds

 

Gene context of Genes, MHC Class II

 

Analytical, diagnostic and therapeutic context of Genes, MHC Class II

References

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