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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

TLR5  -  toll-like receptor 5

Gallus gallus

 
 
 
 
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Disease relevance of TLR5

  • Collectively, the data represent the identification and functional characterization of a nonmammalian TLR5 and indicate a role in restricting the entry of flagellated Salmonella into systemic sites of the chicken [1].
 

High impact information on TLR5

  • In chickens, the differential biology of Salmonella serovars (systemic versus gut-restricted localization) correlates with the presence or absence of flagella, a known TLR5 agonist [1].
  • Chicken TLR5 (chTLR5) exhibits conserved sequence and structural similarity with mammalian TLR5 and is expressed in tissues and cell populations of immunological and stromal origin [1].

References

  1. Identification and functional characterization of chicken toll-like receptor 5 reveals a fundamental role in the biology of infection with Salmonella enterica serovar typhimurium. Iqbal, M., Philbin, V.J., Withanage, G.S., Wigley, P., Beal, R.K., Goodchild, M.J., Barrow, P., McConnell, I., Maskell, D.J., Young, J., Bumstead, N., Boyd, Y., Smith, A.L. Infect. Immun. (2005) [Pubmed]
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