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Gene Review

Tlr5  -  toll-like receptor 5

Mus musculus

Synonyms: Toll-like receptor 5
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Disease relevance of Tlr5


High impact information on Tlr5


Biological context of Tlr5


Anatomical context of Tlr5

  • Although flagellin activation of the IL-1R-associated kinase and induction of TNF-alpha synthesis are dependent on TLR5 and not TLR4, we have found that flagellin stimulates NO in macrophages via a pathway that requires TLR5 and TLR4 [8].
  • Recent work showed that flagellin, the monomeric subunit of bacterial flagella, triggers innate immune responses mediated by Toll-like receptor 5 [9].
  • Therefore, like the recognition site of the innate immune receptor Toll-like receptor 5, three of four FliC epitopes recognized by CD4+ T cells colocalize in the D0/D1 domains of FliC [10].

Physical interactions of Tlr5


Analytical, diagnostic and therapeutic context of Tlr5

  • Northern blot analysis reveals that Tlr5 is expressed predominantly in liver and lung with low-level expression in most other tissues examined [1].


  1. Cloning and characterization of the murine toll-like receptor 5 (Tlr5) gene: sequence and mRNA expression studies in Salmonella-susceptible MOLF/Ei mice. Sebastiani, G., Leveque, G., Larivière, L., Laroche, L., Skamene, E., Gros, P., Malo, D. Genomics (2000) [Pubmed]
  2. Bacterial flagellin is an effective adjuvant for CD4+ T cells in vivo. McSorley, S.J., Ehst, B.D., Yu, Y., Gewirtz, A.T. J. Immunol. (2002) [Pubmed]
  3. Flagellin enhances NK cell proliferation and activation directly and through dendritic cell-NK cell interactions. Tsujimoto, H., Uchida, T., Efron, P.A., Scumpia, P.O., Verma, A., Matsumoto, T., Tschoeke, S.K., Ungaro, R.F., Ono, S., Seki, S., Clare-Salzler, M.J., Baker, H.V., Mochizuki, H., Ramphal, R., Moldawer, L.L. J. Leukoc. Biol. (2005) [Pubmed]
  4. Flagellin-deficient Legionella mutants evade caspase-1- and Naip5-mediated macrophage immunity. Ren, T., Zamboni, D.S., Roy, C.R., Dietrich, W.F., Vance, R.E. PLoS Pathog. (2006) [Pubmed]
  5. Detection of pathogenic intestinal bacteria by Toll-like receptor 5 on intestinal CD11c+ lamina propria cells. Uematsu, S., Jang, M.H., Chevrier, N., Guo, Z., Kumagai, Y., Yamamoto, M., Kato, H., Sougawa, N., Matsui, H., Kuwata, H., Hemmi, H., Coban, C., Kawai, T., Ishii, K.J., Takeuchi, O., Miyasaka, M., Takeda, K., Akira, S. Nat. Immunol. (2006) [Pubmed]
  6. Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1beta in salmonella-infected macrophages. Franchi, L., Amer, A., Body-Malapel, M., Kanneganti, T.D., Ozören, N., Jagirdar, R., Inohara, N., Vandenabeele, P., Bertin, J., Coyle, A., Grant, E.P., Núñez, G. Nat. Immunol. (2006) [Pubmed]
  7. Bacterial flagellin is a dominant antigen in Crohn disease. Lodes, M.J., Cong, Y., Elson, C.O., Mohamath, R., Landers, C.J., Targan, S.R., Fort, M., Hershberg, R.M. J. Clin. Invest. (2004) [Pubmed]
  8. Induction of macrophage nitric oxide production by Gram-negative flagellin involves signaling via heteromeric Toll-like receptor 5/Toll-like receptor 4 complexes. Mizel, S.B., Honko, A.N., Moors, M.A., Smith, P.S., West, A.P. J. Immunol. (2003) [Pubmed]
  9. Comparison of inflammation, organ damage, and oxidant stress induced by Salmonella enterica serovar Muenchen flagellin and serovar Enteritidis lipopolysaccharide. Liaudet, L., Murthy, K.G., Mabley, J.G., Pacher, P., Soriano, F.G., Salzman, A.L., Szabó, C. Infect. Immun. (2002) [Pubmed]
  10. CD4+-T-cell responses generated during murine Salmonella enterica serovar Typhimurium infection are directed towards multiple epitopes within the natural antigen FliC. Bergman, M.A., Cummings, L.A., Alaniz, R.C., Mayeda, L., Fellnerova, I., Cookson, B.T. Infect. Immun. (2005) [Pubmed]
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