Gene Review:
TLR5 - toll-like receptor 5
Homo sapiens
Synonyms:
FLJ10052, MELIOS, MGC126430, MGC126431, SLE1, ...
Mantovani,
Hantgan,
Mizel,
Endrich,
Hayashi,
Powles,
Eck,
D'amico,
Lugering,
Yamamoto,
Kar,
Corcoran,
Polentarutti,
Navas,
Ding,
Eck,
Kay,
Lee,
Mizel,
de Veer,
DiDonato,
Ovigne,
Akashi,
Mitchell,
Schmausser,
Allavena,
Maaser,
Barrett,
Crowe,
Madara,
Sun,
Stoppacciaro,
Mancinelli,
Lyons,
Deb,
Cookson,
Miyake,
Tallant,
Smith,
Snipes,
Aderem,
Lupica,
Bosisio,
van't Veer,
Kucharzik,
Johnson,
Douglas,
Andrulis,
Fry,
Park,
Li,
Smith,
Spahn,
Muzio,
von Eiff,
Ruco,
Penton-Rol,
Josenhans,
Endrich,
Heidemann,
Domschke,
Tsoi,
Schmausser,
Andersen-Nissen,
Matsuura,
Baker,
Goldberg,
Ryan,
Higuchi,
Müller-Hermelink,
Andrulis,
Hijiya,
Müller-Hermelink,
O'Brien,
Gewirtz,
Strobe,
Bergman,
Godowski,
Kabelitz,
West,
Fitzmaurice,
Lugering,
Binion,
Brown,
Podor,
- Borrelia burgdorferi lipoprotein-mediated TLR2 stimulation causes the down-regulation of TLR5 in human monocytes. Cabral, E.S., Gelderblom, H., Hornung, R.L., Munson, P.J., Martin, R., Marques, A.R. J. Infect. Dis. (2006)
- Human airway epithelial cells sense Pseudomonas aeruginosa infection via recognition of flagellin by Toll-like receptor 5. Zhang, Z., Louboutin, J.P., Weiner, D.J., Goldberg, J.B., Wilson, J.M. Infect. Immun. (2005)
- Normal keratinocytes express Toll-like receptors (TLRs) 1, 2 and 5: modulation of TLR expression in chronic plaque psoriasis. Baker, B.S., Ovigne, J.M., Powles, A.V., Corcoran, S., Fry, L. Br. J. Dermatol. (2003)
- Epithelial toll-like receptor 5 is constitutively localized in the mouse cecum and exhibits distinctive down-regulation during experimental colitis. Ortega-Cava, C.F., Ishihara, S., Rumi, M.A., Aziz, M.M., Kazumori, H., Yuki, T., Mishima, Y., Moriyama, I., Kadota, C., Oshima, N., Amano, Y., Kadowaki, Y., Ishimura, N., Kinoshita, Y. Clinical and vaccine immunology : CVI. (2006)
- Innate immunity mediated by TLR5 as a novel antiinflammatory target for cystic fibrosis lung disease. Blohmke, C.J., Victor, R.E., Hirschfeld, A.F., Elias, I.M., Hancock, D.G., Lane, C.R., Davidson, A.G., Wilcox, P.G., Smith, K.D., Overhage, J., Hancock, R.E., Turvey, S.E. J. Immunol. (2008)
- The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Hayashi, F., Smith, K.D., Ozinsky, A., Hawn, T.R., Yi, E.C., Goodlett, D.R., Eng, J.K., Akira, S., Underhill, D.M., Aderem, A. Nature (2001)
- Toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility. Smith, K.D., Andersen-Nissen, E., Hayashi, F., Strobe, K., Bergman, M.A., Barrett, S.L., Cookson, B.T., Aderem, A. Nat. Immunol. (2003)
- A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. Hawn, T.R., Verbon, A., Lettinga, K.D., Zhao, L.P., Li, S.S., Laws, R.J., Skerrett, S.J., Beutler, B., Schroeder, L., Nachman, A., Ozinsky, A., Smith, K.D., Aderem, A. J. Exp. Med. (2003)
- Expression and function of Toll-like receptors in T lymphocytes. Kabelitz, D. Curr. Opin. Immunol. (2007)
- Toll-like receptors 2 and 4 are up-regulated during intestinal inflammation. Hausmann, M., Kiessling, S., Mestermann, S., Webb, G., Spöttl, T., Andus, T., Schölmerich, J., Herfarth, H., Ray, K., Falk, W., Rogler, G. Gastroenterology (2002)
- Gene expression clusters of a lipopolysaccharide-stimulated pathway in peripheral blood monocytes of Japanese patients with Crohn's disease. Naito, Y., Takagi, T., Mizushima, K., Ueta, M., Kinoshita, S., Handa, O., Kokura, S., Ichikawa, H., Yoshida, N., Yoshikawa, T. Aliment. Pharmacol. Ther. (2006)
- Identification of a transcript encoding a soluble form of toll-like receptor 5 (TLR5) in Atlantic salmon during Aeromonas salmonicida infection. Tsoi, S., Park, K.C., Kay, H.H., O'Brien, T.J., Podor, E., Sun, G., Douglas, S.E., Brown, L.L., Johnson, S.C. Vet. Immunol. Immunopathol. (2006)
- Toll-like receptor (TLR) 2 and TLR5, but not TLR4, are required for Helicobacter pylori-induced NF-kappa B activation and chemokine expression by epithelial cells. Smith, M.F., Mitchell, A., Li, G., Ding, S., Fitzmaurice, A.M., Ryan, K., Crowe, S., Goldberg, J.B. J. Biol. Chem. (2003)
- Cooperative interactions between flagellin and SopE2 in the epithelial interleukin-8 response to Salmonella enterica serovar typhimurium infection. Huang, F.C., Werne, A., Li, Q., Galyov, E.E., Walker, W.A., Cherayil, B.J. Infect. Immun. (2004)
- Gram-negative flagellin-induced self-tolerance is associated with a block in interleukin-1 receptor-associated kinase release from toll-like receptor 5. Mizel, S.B., Snipes, J.A. J. Biol. Chem. (2002)
- A stop codon polymorphism of Toll-like receptor 5 is associated with resistance to systemic lupus erythematosus. Hawn, T.R., Wu, H., Grossman, J.M., Hahn, B.H., Tsao, B.P., Aderem, A. Proc. Natl. Acad. Sci. U.S.A. (2005)
- A family of human receptors structurally related to Drosophila Toll. Rock, F.L., Hardiman, G., Timans, J.C., Kastelein, R.A., Bazan, J.F. Proc. Natl. Acad. Sci. U.S.A. (1998)
- Role of MyD88 in phosphatidylinositol 3-kinase activation by flagellin/toll-like receptor 5 engagement in colonic epithelial cells. Rhee, S.H., Kim, H., Moyer, M.P., Pothoulakis, C. J. Biol. Chem. (2006)
- Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. Muzio, M., Bosisio, D., Polentarutti, N., D'amico, G., Stoppacciaro, A., Mancinelli, R., van't Veer, C., Penton-Rol, G., Ruco, L.P., Allavena, P., Mantovani, A. J. Immunol. (2000)
- The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. Means, T.K., Hayashi, F., Smith, K.D., Aderem, A., Luster, A.D. J. Immunol. (2003)
- Pseudomonas aeruginosa flagella activate airway epithelial cells through asialoGM1 and toll-like receptor 2 as well as toll-like receptor 5. Adamo, R., Sokol, S., Soong, G., Gomez, M.I., Prince, A. Am. J. Respir. Cell Mol. Biol. (2004)
- AsialoGM1-Mediated IL-8 Release by Human Corneal Epithelial Cells Requires Coexpression of TLR5. Du, J.W., Zhang, F., Cap??-Aponte, J.E., Tachado, S.D., Zhang, J., Yu, F.S., Sack, R.A., Koziel, H., Reinach, P.S. Invest. Ophthalmol. Vis. Sci. (2006)
- Identification of a sequence in human toll-like receptor 5 required for the binding of Gram-negative flagellin. Mizel, S.B., West, A.P., Hantgan, R.R. J. Biol. Chem. (2003)
- Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. Gewirtz, A.T., Navas, T.A., Lyons, S., Godowski, P.J., Madara, J.L. J. Immunol. (2001)
- Cutting Edge: Loss of TLR2, TLR4, and TLR5 on Langerhans Cells Abolishes Bacterial Recognition. van der Aar, A.M., Sylva-Steenland, R.M., Bos, J.D., Kapsenberg, M.L., de Jong, E.C., Teunissen, M.B. J. Immunol. (2007)
- Bacterial flagellin inhibits T cell receptor-mediated activation of T cells by inducing suppressor of cytokine signalling-1 (SOCS-1). Okugawa, S., Yanagimoto, S., Tsukada, K., Kitazawa, T., Koike, K., Kimura, S., Nagase, H., Hirai, K., Ota, Y. Cell. Microbiol. (2006)
- Effects of flagellin on innate and adaptive immunity. Honko, A.N., Mizel, S.B. Immunol. Res. (2005)
- Toll-like receptors TLR4, TLR5 and TLR9 on gastric carcinoma cells: an implication for interaction with Helicobacter pylori. Schmausser, B., Andrulis, M., Endrich, S., Müller-Hermelink, H.K., Eck, M. Int. J. Med. Microbiol. (2005)
- Gangliosides act as co-receptors for Salmonella enteritidis FliC and promote FliC induction of human beta-defensin-2 expression in Caco-2 cells. Ogushi, K., Wada, A., Niidome, T., Okuda, T., Llanes, R., Nakayama, M., Nishi, Y., Kurazono, H., Smith, K.D., Aderem, A., Moss, J., Hirayama, T. J. Biol. Chem. (2004)
- Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4+CD25+ T regulatory cells. Crellin, N.K., Garcia, R.V., Hadisfar, O., Allan, S.E., Steiner, T.S., Levings, M.K. J. Immunol. (2005)
- Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-kappa B and proinflammatory gene program activation in intestinal epithelial cells. Tallant, T., Deb, A., Kar, N., Lupica, J., de Veer, M.J., DiDonato, J.A. BMC Microbiol. (2004)
- MEK is a key modulator for TLR5-induced interleukin-8 and MIP3alpha gene expression in non-transformed human colonic epithelial cells. Rhee, S.H., Keates, A.C., Moyer, M.P., Pothoulakis, C. J. Biol. Chem. (2004)
- Possible involvement of toll-like receptor 4 in endothelial cell activation of larger vessels in response to lipopolysaccharide. Hijiya, N., Miyake, K., Akashi, S., Matsuura, K., Higuchi, Y., Yamamoto, S. Pathobiology (2002)
- Microbial induction of CARD15 expression in intestinal epithelial cells via toll-like receptor 5 triggers an antibacterial response loop. Begue, B., Dumant, C., Bambou, J.C., Beaulieu, J.F., Chamaillard, M., Hugot, J.P., Goulet, O., Schmitz, J., Philpott, D.J., Cerf-Bensussan, N., Ruemmele, F.M. J. Cell. Physiol. (2006)
- Expression and subcellular distribution of toll-like receptors TLR4, TLR5 and TLR9 on the gastric epithelium in Helicobacter pylori infection. Schmausser, B., Andrulis, M., Endrich, S., Lee, S.K., Josenhans, C., Müller-Hermelink, H.K., Eck, M. Clin. Exp. Immunol. (2004)
- Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria. Feuillet, V., Medjane, S., Mondor, I., Demaria, O., Pagni, P.P., Galán, J.E., Flavell, R.A., Alexopoulou, L. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Human intestinal microvascular endothelial cells express Toll-like receptor 5: a binding partner for bacterial flagellin. Maaser, C., Heidemann, J., von Eiff, C., Lugering, A., Spahn, T.W., Binion, D.G., Domschke, W., Lugering, N., Kucharzik, T. J. Immunol. (2004)