The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

PARL  -  presenilin associated, rhomboid-like

Homo sapiens

Synonyms: Mitochondrial intramembrane cleaving protease PARL, PRO2207, PSARL, PSARL1, PSENIP2, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of PARL

  • Previous reports indicate that the two-allele ER PvuII polymorphism could be associated with ER expression in breast cancer (Hill et al., Cancer Res., 49: 145-148, 1989) as well as with patient age at time of tumor diagnosis (Parl et al., Breast Cancer Res. Treat., 14: 57-64, 1989) [1].

High impact information on PARL


Other interactions of PARL

  • In eukaryotes, two distinct, ancient acquisitions apparently gave rise to the two major subfamilies, typified by rhomboid and PARL (presenilins-associated rhomboid-like protein), respectively [5].


  1. Analysis of the PvuII restriction fragment-length polymorphism and exon structure of the estrogen receptor gene in breast cancer and peripheral blood. Yaich, L., Dupont, W.D., Cavener, D.R., Parl, F.F. Cancer Res. (1992) [Pubmed]
  2. OPA1 and PARL keep a lid on apoptosis. Gottlieb, E. Cell (2006) [Pubmed]
  3. PARL Leu262Val is not associated with fasting insulin levels in UK populations. Fawcett, K.A., Wareham, N.J., Luan, J., Syddall, H., Cooper, C., O'rahilly, S., Day, I.N., Sandhu, M.S., Barroso, I. Diabetologia (2006) [Pubmed]
  4. Contrasting microsatellite variation between subalpine and western larch, two closely related species with different distribution patterns. Khasa, D.P., Jaramillo-Correa, J.P., Jaquish, B., Bousquet, J. Mol. Ecol. (2006) [Pubmed]
  5. The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers. Koonin, E.V., Makarova, K.S., Rogozin, I.B., Davidovic, L., Letellier, M.C., Pellegrini, L. Genome Biol. (2003) [Pubmed]
WikiGenes - Universities