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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

MED29  -  mediator complex subunit 29

Homo sapiens

Synonyms: DKFZp434H247, IXL, Intersex-like protein, Mediator complex subunit 29, Mediator of RNA polymerase II transcription subunit 29
 
 
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Disease relevance of IXL

 

High impact information on IXL

  • In the present study, we report the identification and characterization of a novel human gene, (Drosophila) intersex-like (IXL), from a human embryonic heart cDNA library [2].
  • IXL, a new subunit of the mammalian Mediator complex, functions as a transcriptional suppressor [2].
  • In COS-7 cells, IXL protein is localized to nucleus and cytoplasm [2].
 

Analytical, diagnostic and therapeutic context of IXL

  • Northern blot analysis indicates that IXL is expressed in various tissues of human adult and during three different developmental stages of embryo [2].

References

  1. Intersex-like (IXL) is a cell survival regulator in pancreatic cancer with 19q13 amplification. Kuuselo, R., Savinainen, K., Azorsa, D.O., Basu, G.D., Karhu, R., Tuzmen, S., Mousses, S., Kallioniemi, A. Cancer Res. (2007) [Pubmed]
  2. IXL, a new subunit of the mammalian Mediator complex, functions as a transcriptional suppressor. Wang, Y., Li, Y., Zeng, W., Zhu, C., Xiao, J., Yuan, W., Wang, Y., Cai, Z., Zhou, J., Liu, M., Wu, X. Biochem. Biophys. Res. Commun. (2004) [Pubmed]
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