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Gene Review:

mfap2 - microfibrillar-associated protein 2

Danio rerio

Synonyms: SO:0000704, fa03c08, magp1, wu:fa03c08, zgc:153818

Chen, E. et al.

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Disease relevance of LOC556677

The essential role for MAGP1 in vascular morphogenesis and function also supports a wide range of clinical applications, including therapeutic targets in vascular disease and cardiovascular tissue engineering [1].

High impact information on LOC556677

This study implicates MAGP1 as a key player in microfibril formation and integrity during development [1].
Integrin function is compromised in magp1 morphant embryos, suggesting that reduced integrin-matrix interaction is the main mechanism for the vascular defects in magp1 morphants [1].

References

Functional analysis of zebrafish microfibril-associated glycoprotein-1 (Magp1) in vivo reveals roles for microfibrils in vascular development and function. Chen, E., Larson, J.D., Ekker, S.C. Blood (2006) [Pubmed]

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MFAP2	Bos taurus
MFAP2	Canis lupus familiaris
MFAP2	Gallus gallus
MFAP2	Homo sapiens
MFAP2	Macaca mulatta
Mfap2	Mus musculus
MFAP2	Pan troglodytes
Mfap2	Rattus norvegicus
mfap2	Xenopus (Silurana) tropicalis

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