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Gene Review

UGGT2  -  UDP-glucose glycoprotein...

Homo sapiens

Synonyms: FLJ10873, FLJ11485, HUGT2, MGC117360, MGC150689, ...
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High impact information on UGCGL2

  • In this report we demonstrate that HUGT2 is localized to the ER in a manner that overlaps the distribution of HUGT1 [1].
  • HUGT1 and HUGT2 mRNAs are broadly expressed in multiple tissues and differ slightly in their tissue distribution [2].
  • Conjugases such as UDP- glucuronosyltransferases with substrates 3-OH benzo(a)pyrene (UGT1) and 4-hydroxybiphenyl (UGT2) and glutathione S-transferase (GST) with substrate 1-chloro-2,4-dinitrobenzene were higher by 72, 69, and 33% in RF and 28, 38, and 24% in rRF groups, respectively [3].

Biological context of UGCGL2

  • The results indicate that the amino-terminal 80% of HUGT1 is required for activation of the catalytic domain, whereas the homologous portion of HUGT2 cannot provide this function [1].
  • The HUGT1 and HUGT2 cDNAs were expressed by transient transfection in COS-1 monkey cells to obtain similar levels of protein localized to the ER [2].


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