The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

UGGT1  -  UDP-glucose glycoprotein...

Homo sapiens

Synonyms: GT, HUGT1, UDP--Glc:glycoprotein glucosyltransferase, UDP-glucose ceramide glucosyltransferase-like 1, UDP-glucose:glycoprotein glucosyltransferase 1, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of UGCGL1

  • To circumvent this, we have used a defective herpes simplex virus vector to overexpress the rat brain glucose transporter (GT) gene under the control of the human cytomegalovirus ie1 promoter [1].
  • To assess the contribution of the HepG2/erythrocyte glucose-transporter (HepG2 GT) gene to the inherited susceptibility to non-insulin-dependent diabetes mellitus (NIDDM), cDNA and genomic probes were used to search for restriction-endonuclease polymorphisms at this locus [2].
  • Microphthalmia, cataracts, and chronic nongranulomatous inflammation involving the anterior and/or posterior segments of the eye were also found. gamma GT is detectable histochemically as early as 11.5 gestational days in the outer neuroectodermal layer and after birth is more abundant in the ciliary body than in the retinal pigment epithelium [3].
  • OBJECTIVE: To examine anxiety levels of women diagnosed with gestational diabetes mellitus (GDM) and to compare these with glucose-tolerant (GT) women at similar stages of pregnancy [4].
  • DESIGN: Midthigh AT, muscle composition, and insulin sensitivity were compared in 11 obese patients with type 2 diabetes mellitus (DM); 40 obese, glucose-tolerant (GT) and 15 lean, GT volunteers; and 38 obese subjects who completed a weight-loss program [5].

Psychiatry related information on UGCGL1

  • However, an interaction was observed between alcohol consumption and glucose tolerance (GT) status [6].
  • In this study, we assessed the GT protein in the frontal cortex, hippocampus, cerebellum, and cerebral microvessels in subjects with Alzheimer's disease (AD) and controls [7].

High impact information on UGCGL1

  • Monoglucosylated glycans are then recreated by the UDP-Glc:glycoprotein glucosyltransferase (GT), and thus recognized again by the lectins, only when linked to improperly folded protein moieties, as GT behaves as a sensor of glycoprotein conformations [8].
  • RNA transcripts encoding the complete human glucose transporter (GT) or fragments of GT corresponding to the NH2-terminal 340 amino acids (GT-N) or the COOH-terminal 148 amino acids (GT-C) were synthesized in vitro from SP6 plasmids [9].
  • Here we demonstrate differential regulation of these two GTs in adipose cells of diabetic and insulin-treated diabetic rats and compare changes in the expression of each GT with marked alterations in insulin-stimulated glucose transport activity [10].
  • In contrast, GTs detected with antisera to the carboxyl terminus of the HepG2 GT or to the human erythrocyte GT show no significant change with diabetes or insulin treatment [10].
  • UDP-glucose:glycoprotein glucosyltransferase (GT) is a key component of the glycoprotein-specific folding and quality control system in the endoplasmic reticulum [11].

Chemical compound and disease context of UGCGL1


Biological context of UGCGL1


Anatomical context of UGCGL1

  • The rat brain glucose transporter (GT) gene is rapidly activated coincident with the initiation of growth in response to oncogenic transformation or the addition of growth factors to quiescent fibroblasts [19].
  • Microinfusion of GT vectors into the rat hippocampus also reduces kainic acid-induced seizure damage in the CA3 cell field [20].
  • GT expressed from vIE1GT was readily immunoprecipitated from membrane fractions of vIE1GT-infected Vero cells [1].
  • Comparisons of gamma GT RNA stability were not possible since nontransformed liver cells (228) contain little or no gamma GT RNA [21].
  • GT-tSBO activity is catalyzed by GT mu which has polymorphic expression in human lymphocytes [22].

Associations of UGCGL1 with chemical compounds

  • Whereas neither catalytic domain displayed detectable activity when expressed alone, co-expression of either catalytic domain with the noncatalytic amino-terminal portion of HUGT1 conferred UDP-Glc binding and transfer of glucose that was specific for unfolded glycoprotein substrates [17].
  • The contribution of the NH2-terminal remainder of HUGT1 to glucosyltransferase function is presently unknown [17].
  • We present crystal structures of the UDP flavonoid/triterpene GT UGT71G1 from Medicago truncatula bound to UDP or UDP-glucose [23].
  • gamma-Glutamyl transpeptidase (EC, gamma GT) is a membrane-bound ectoenzyme that plays an important role in the metabolism of glutathione [24].
  • Thirteen patients were homozygous for the genetic polymorphism of MDR1 (n = 7 for guanine, n = 6 for thymidine), whereas 17 patients were heterozygous (GT) [25].

Other interactions of UGCGL1


Analytical, diagnostic and therapeutic context of UGCGL1

  • Northern blotting reveals that the adipose/muscle GT mRNA decreases 50% with diabetes and increases to 6.8-fold control (13-fold diabetic) levels with insulin treatment [10].
  • By using indirect double immunofluorescence techniques, vIE1GT was shown to be capable of enhancing GT expression in cultured hippocampal neurons and glia [1].
  • When examined 2 days later, GT expression from vIE1GT was demonstrated in hippocampal neurons by in situ hybridization; a small but significant increase in glucose transport was detected in tissue immediately surrounding the injection site by 2-deoxy[14C]glucose uptake and autoradiography [1].
  • Using a reverse transcriptase-polymerase chain reaction, we found that type I (but not types II or III) gamma GT RNA is made by the mouse eye; the gamma GT(I)rasT24 transgene transcription product was detected in the eyes of all five transgenic lines [3].
  • Examples, based on the literature and our own work, illustrate the increase of A and GT by cortisone acetate premedication as well as long-term oral contraceptive medication [27].


  1. Altering central nervous system physiology with a defective herpes simplex virus vector expressing the glucose transporter gene. Ho, D.Y., Mocarski, E.S., Sapolsky, R.M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  2. Polymorphisms of HepG2/erythrocyte glucose-transporter gene. Linkage relationships and implications for genetic analysis of NIDDM. Kaku, K., Matsutani, A., Mueckler, M., Permutt, M.A. Diabetes (1990) [Pubmed]
  3. Expression of the rasT24 oncogene in the ciliary body pigment epithelium and retinal pigment epithelium results in hyperplasia, adenoma, and adenocarcinoma. Chévez-Barrios, P., Schaffner, D.L., Barrios, R., Overbeek, P.A., Lebovitz, R.M., Lieberman, M.W. Am. J. Pathol. (1993) [Pubmed]
  4. Gestational diabetes mellitus: is a diagnosis associated with an increase in maternal anxiety and stress in the short and intermediate term? Daniells, S., Grenyer, B.F., Davis, W.S., Coleman, K.J., Burgess, J.A., Moses, R.G. Diabetes Care (2003) [Pubmed]
  5. Thigh adipose tissue distribution is associated with insulin resistance in obesity and in type 2 diabetes mellitus. Goodpaster, B.H., Thaete, F.L., Kelley, D.E. Am. J. Clin. Nutr. (2000) [Pubmed]
  6. Is insulin sensitivity a causal intermediate in the relationship between alcohol consumption and carotid atherosclerosis?: the insulin resistance and atherosclerosis study. Cooper, D.E., Goff, D.C., Bell, R.A., Zaccaro, D., Mayer-Davis, E.J., Karter, A.J. Diabetes Care (2002) [Pubmed]
  7. Abnormalities of the glucose transporter at the blood-brain barrier and in brain in Alzheimer's disease. Kalaria, R.N., Harik, S.I. Prog. Clin. Biol. Res. (1989) [Pubmed]
  8. Protein glucosylation and its role in protein folding. Parodi, A.J. Annu. Rev. Biochem. (2000) [Pubmed]
  9. The human glucose transporter can insert posttranslationally into microsomes. Mueckler, M., Lodish, H.F. Cell (1986) [Pubmed]
  10. Differential regulation of two glucose transporters in adipose cells from diabetic and insulin-treated diabetic rats. Kahn, B.B., Charron, M.J., Lodish, H.F., Cushman, S.W., Flier, J.S. J. Clin. Invest. (1989) [Pubmed]
  11. Minor folding defects trigger local modification of glycoproteins by the ER folding sensor GT. Ritter, C., Quirin, K., Kowarik, M., Helenius, A. EMBO J. (2005) [Pubmed]
  12. Virucidal Activity of a GT-Rich Oligonucleotide against Herpes Simplex Virus Mediated by Glycoprotein B. Shogan, B., Kruse, L., Mulamba, G.B., Hu, A., Coen, D.M. J. Virol. (2006) [Pubmed]
  13. Analysis of the sequences of human beta-1,4-galactosyltransferase cDNA clones. Chatterjee, S.K., Mukerjee, S., Tripathi, P.K. Int. J. Biochem. Cell Biol. (1995) [Pubmed]
  14. Tubulointerstitial nephropathy persisting 20 months after discontinuation of chronic intake of germanium lactate citrate. Hess, B., Raisin, J., Zimmermann, A., Horber, F., Bajo, S., Wyttenbach, A., Jaeger, P. Am. J. Kidney Dis. (1993) [Pubmed]
  15. Multivariate analyses as aids to diagnosis and assessment of prognosis in gastrointestinal cancer. de Mello, J., Struthers, L., Turner, R., Cooper, E.H., Giles, G.R. Br. J. Cancer (1983) [Pubmed]
  16. Insulin sensitivity in Turner's syndrome: influence of GH treatment. Radetti, G., Pasquino, B., Gottardi, E., Boscolo Contadin, I., Aimaretti, G., Rigon, F. Eur. J. Endocrinol. (2004) [Pubmed]
  17. The noncatalytic portion of human UDP-glucose: glycoprotein glucosyltransferase I confers UDP-glucose binding and transferase function to the catalytic domain. Arnold, S.M., Kaufman, R.J. J. Biol. Chem. (2003) [Pubmed]
  18. Two homologues encoding human UDP-glucose:glycoprotein glucosyltransferase differ in mRNA expression and enzymatic activity. Arnold, S.M., Fessler, L.I., Fessler, J.H., Kaufman, R.J. Biochemistry (2000) [Pubmed]
  19. Transformation stimulates glucose transporter gene expression in the absence of protein kinase C. Hiraki, Y., Garcia de Herreros, A., Birnbaum, M.J. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  20. Herpes simplex virus vectors overexpressing the glucose transporter gene protect against seizure-induced neuron loss. Lawrence, M.S., Ho, D.Y., Dash, R., Sapolsky, R.M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  21. Two genes associated with liver cancer are regulated by different mechanisms in rasT24 transformed liver epithelial cells. Li, Y.C., Lieberman, M.W. Oncogene (1989) [Pubmed]
  22. Glutathione S-transferase mu in human lymphocyte and liver: role in modulating formation of carcinogen-derived DNA adducts. Liu, Y.H., Taylor, J., Linko, P., Lucier, G.W., Thompson, C.L. Carcinogenesis (1991) [Pubmed]
  23. Crystal structures of a multifunctional triterpene/flavonoid glycosyltransferase from Medicago truncatula. Shao, H., He, X., Achnine, L., Blount, J.W., Dixon, R.A., Wang, X. Plant Cell (2005) [Pubmed]
  24. Human lung expresses unique gamma-glutamyl transpeptidase transcripts. Wetmore, L.A., Gerard, C., Drazen, J.M. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  25. MDR1 gene-related clonal selection and P-glycoprotein function and expression in relapsed or refractory acute myeloid leukemia. van den Heuvel-Eibrink, M.M., Wiemer, E.A., de Boevere, M.J., van der Holt, B., Vossebeld, P.J., Pieters, R., Sonneveld, P. Blood (2001) [Pubmed]
  26. The interplay between folding-facilitating mechanisms in Trypanosoma cruzi endoplasmic reticulum. Conte, I., Labriola, C., Cazzulo, J.J., Docampo, R., Parodi, A.J. Mol. Biol. Cell (2003) [Pubmed]
  27. Glucose tolerance and insulin release, a mathematical approach. II. Approximation of the peripheral insulin resistance after oral glucose loading. Sluiter, W.J., Erkelens, D.W., Terpstra, P., Reitsma, W.D., Doorenbos, H. Diabetes (1976) [Pubmed]
WikiGenes - Universities