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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

Gde1  -  glycerophosphodiester phosphodiesterase 1

Mus musculus

Synonyms: 1200003M13Rik, Glycerophosphodiester phosphodiesterase 1, MIR16, Membrane-interacting protein of RGS16, Mir16, ...
 
 
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High impact information on Mir16

  • Analysis of substrate specificity shows that GDE1/MIR16 selectively hydrolyzes GPI over glycerophosphocholine [1].
  • Previously we identified MIR16 (membrane interacting protein of RGS16) as an integral membrane glycoprotein that interacts with regulator of G protein signaling proteins and shares significant sequence homology with bacterial glycerophosphodiester phosphodiesterases (GDEs), suggesting that it is a putative mammalian GDE [1].
  • Our results show an inverse correlation between the capacity to migrate and the levels of RGS1, RGS9 and RGS16 for both naive and regulatory T cells [2].

References

  1. GDE1/MIR16 is a glycerophosphoinositol phosphodiesterase regulated by stimulation of G protein-coupled receptors. Zheng, B., Berrie, C.P., Corda, D., Farquhar, M.G. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  2. Differential expression of regulator of G-protein signalling transcripts and in vivo migration of CD4+ naïve and regulatory T cells. Agenès, F., Bosco, N., Mascarell, L., Fritah, S., Ceredig, R. Immunology (2005) [Pubmed]
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