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Chemical Compound Review

L-alpha-Glycerylphosphorylcholine     2-[[(2R)-2,3- dihydroxypropoxy]-hydroxy...

Synonyms: DB04660, AC1L971T, C00670, CH5, Glycerophosphocholine, ...
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Disease relevance of L-alpha-Glycerylphosphorylcholine


Psychiatry related information on L-alpha-Glycerylphosphorylcholine


High impact information on L-alpha-Glycerylphosphorylcholine


Chemical compound and disease context of L-alpha-Glycerylphosphorylcholine


Biological context of L-alpha-Glycerylphosphorylcholine


Anatomical context of L-alpha-Glycerylphosphorylcholine

  • (Chilton, F. H., Ellis, J. M., Olson, S. C., and Wykle, R. L. (1984) J. Biol. Chem. 259, 12014-12019) indicate that in human neutrophils the metabolism of alkenylacyl-GPE and alkylacyl-sn-glycero-3-phosphocholine (GPC) are strikingly similar with regard to arachidonate metabolism [23].
  • We confirm that ionophore A23187 induces substantial [(3)H]arachidonate release from differentiated but not control U937 cells, and electrospray ionization mass spectrometric (ESI/MS) analyses indicate that differentiated cells contain a higher proportion of arachidonate-containing GPC species than control cells [24].
  • Testes or other tissues of iPLA(2)beta(-/-) mice express no iPLA(2)beta mRNA or protein, but iPLA(2)beta(-/-) testes are not deficient in 20:4-containing glycerophosphocholine lipids, indicating that iPLA(2)beta does not play an obligatory role in formation of such lipids in that tissue [19].
  • Eukaryotic cells control the levels of their major membrane lipid, phosphatidylcholine (PtdCho), by balancing synthesis with degradation via deacylation to glycerophosphocholine (GroPCho) [25].
  • Previous studies have not recognized that phosphocholine and glycerophosphocholine exist in human milk [26].

Associations of L-alpha-Glycerylphosphorylcholine with other chemical compounds


Gene context of L-alpha-Glycerylphosphorylcholine


Analytical, diagnostic and therapeutic context of L-alpha-Glycerylphosphorylcholine


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