Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

PRMT8 - protein arginine methyltransferase 8

Homo sapiens

Synonyms: HRMT1L3, HRMT1L4, Heterogeneous nuclear ribonucleoprotein methyltransferase-like protein 4, Protein arginine N-methyltransferase 8

Lee, J. et al.

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High impact information on PRMT8

PRMT8 is thus an active arginine methyltransferase that is membrane-associated and tissue-specific, two firsts for this family of enzymes [1].
A search of the human genome for additional members of the protein arginine N-methyltransferase (PRMT) family of enzymes has identified a gene on chromosome 12 that we have termed PRMT8 [1].
The myristoylation of PRMT8 results in its association with the plasma membrane [1].
The unique N-terminal end harbors a myristoylation motif, and we have shown here that PRMT8 is indeed modified by the attachment of a myristate to the glycine residue after the initiator methionine [1].
PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family [1].

References

PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family. Lee, J., Sayegh, J., Daniel, J., Clarke, S., Bedford, M.T. J. Biol. Chem. (2005) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

PRMT8	Bos taurus
PRMT8	Canis lupus familiaris
LOC556054	Danio rerio
PRMT8	Gallus gallus
LOC709826	Macaca mulatta
Prmt8	Mus musculus
PRMT8	Pan troglodytes
Prmt8	Rattus norvegicus
prmt8	Xenopus (Silurana) tropicalis

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