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Gene Review:

PRRG2 - proline rich Gla (G-carboxyglutamic acid) 2

Homo sapiens

Synonyms: PRGP2, Proline-rich Gla protein 2, Proline-rich gamma-carboxyglutamic acid protein 2, TMG2, Transmembrane gamma-carboxyglutamic acid protein 2

Kulman, J.D. et al., Kulman, J.D. et al.

Haldeman, Harris, Davie, Kulman,

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High impact information on PRRG2

Accordingly, these two proteins have been called proline-rich Gla proteins (PRGP1 and PRGP2) [1].

Biological context of PRRG2

Unlike the gamma-carboxyglutamic acid domain-containing proteins of the blood coagulation cascade, the two PRGPs are expressed in a variety of extrahepatic tissues, with PRGP1 and PRGP2 most abundantly expressed in the spinal cord and thyroid, respectively, among those tissues tested [1].

Physical interactions of PRRG2

In a yeast two-hybrid screen that used the C-terminal cytoplasmic region of PRGP2 as bait, we identified the WW domain-containing transcriptional coactivator Yes-associated protein (YAP) as a binding partner for PRGP2 [2].

References

Primary structure and tissue distribution of two novel proline-rich gamma-carboxyglutamic acid proteins. Kulman, J.D., Harris, J.E., Haldeman, B.A., Davie, E.W. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
Proline-rich Gla protein 2 is a cell-surface vitamin K-dependent protein that binds to the transcriptional coactivator Yes-associated protein. Kulman, J.D., Harris, J.E., Xie, L., Davie, E.W. Proc. Natl. Acad. Sci. U.S.A. (2007) [Pubmed]

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PRRG2	Bos taurus
PRRG2	Canis lupus familiaris
prrg2	Danio rerio
PRRG2	Macaca mulatta
Prrg2	Mus musculus
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Prrg2	Rattus norvegicus
prrg4	Xenopus (Silurana) tropicalis

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