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Gene Review:

PRRG1 - proline rich Gla (G-carboxyglutamic acid) 1

Homo sapiens

Synonyms: PRGP1, Proline-rich Gla protein 1, Proline-rich gamma-carboxyglutamic acid protein 1, TMG1, Transmembrane gamma-carboxyglutamic acid protein 1

Kulman, J.D. et al., Stanley, T.B. et al., Christensen, T. et al.

Kulman, Harris, Haldeman, Davie,

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Disease relevance of PRRG1

Human cells of the established glioblastoma cell line TMG-1 were used [1].

High impact information on PRRG1

Accordingly, these two proteins have been called proline-rich Gla proteins (PRGP1 and PRGP2) [2].
Primary structure and tissue distribution of two novel proline-rich gamma-carboxyglutamic acid proteins [2].
The Ki values for six of the propeptides (factor X, matrix Gla protein, factor VII, factor IX, PRGP1, and protein S) were between 2-35 nM, with the factor X propeptide having the tightest affinity [3].

Biological context of PRRG1

Unlike the gamma-carboxyglutamic acid domain-containing proteins of the blood coagulation cascade, the two PRGPs are expressed in a variety of extrahepatic tissues, with PRGP1 and PRGP2 most abundantly expressed in the spinal cord and thyroid, respectively, among those tissues tested [2].

References

Single-strand breaks in the DNA of human cells exposed to visible light from phototherapy lamps in the presence and absence of bilirubin. Christensen, T., Reitan, J.B., Kinn, G. J. Photochem. Photobiol. B, Biol. (1990) [Pubmed]
Primary structure and tissue distribution of two novel proline-rich gamma-carboxyglutamic acid proteins. Kulman, J.D., Harris, J.E., Haldeman, B.A., Davie, E.W. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
The propeptides of the vitamin K-dependent proteins possess different affinities for the vitamin K-dependent carboxylase. Stanley, T.B., Jin, D.Y., Lin, P.J., Stafford, D.W. J. Biol. Chem. (1999) [Pubmed]

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