Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Gene Review:

ADAM21 - ADAM metallopeptidase domain 21

Homo sapiens

Synonyms: ADAM 21, ADAM31, Disintegrin and metalloproteinase domain-containing protein 21

Xu, G. et al., Hooft van Huijsduijnen, R., Poindexter, K. et al.

Hooft van Huijsduijnen,

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High impact information on ADAM21

ADAM 21 was 2-fold more potent than ADAM 15 and 6-fold more potent than ADAMs 17 and 19 at preventing virus replication [1].
In addition, three pseudogenes were isolated; one of which evolved from ADAM21 [2].
Two novel membrane disintegrin-metalloproteases, ADAM 20 and ADAM 21 were cloned from a human testis cDNA library [3].

References

The biological effects of structural variation at the meta position of the aromatic rings and at the end of the alkenyl chain in the alkenyldiarylmethane series of non-nucleoside reverse transcriptase inhibitors. Xu, G., Micklatcher, M., Silvestri, M.A., Hartman, T.L., Burrier, J., Osterling, M.C., Wargo, H., Turpin, J.A., Buckheit, R.W., Cushman, M. J. Med. Chem. (2001) [Pubmed]
The identification of seven metalloproteinase-disintegrin (ADAM) genes from genomic libraries. Poindexter, K., Nelson, N., DuBose, R.F., Black, R.A., Cerretti, D.P. Gene (1999) [Pubmed]
ADAM 20 and 21; two novel human testis-specific membrane metalloproteases with similarity to fertilin-alpha. Hooft van Huijsduijnen, R. Gene (1998) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

ADAM21	Bos taurus
ADAM21	Canis lupus familiaris
LOC100857840	Gallus gallus
ADAM21	Macaca mulatta
Adam21	Mus musculus
LOC467494	Pan troglodytes

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