Disease relevance of PANX2

• According to brain cancer gene expression database REMBRANDT, PANX2 expression levels can predict post diagnosis survival for patients with glial tumors [1].

High impact information on PANX2

• Our results indicated that Panx1 and Panx2 are abundantly expressed in the retina, and may therefore contribute to the electrical and metabolic coupling, or to signaling between retinal neurons via the secondary messengers [2].
• Mammalian pannexins PANX1 and PANX3 are closely related, with PANX2 more distant [3].
• RESULTS: Panx1 and Panx2 expression peaked in lens epithelial cells prior to differentiation [4].
• So far three pannexins were described in rodent and human genomes: Panx1, Panx2 and Panx3 [1].

Anatomical context of PANX2

• We have cloned the genes PANX1, PANX2 and PANX3, encoding putative gap junction proteins homologous to invertebrate innexins, which constitute a new family of mammalian proteins called pannexins [3].

Analytical, diagnostic and therapeutic context of PANX2

• Expression of the Panx1 and Panx2 members of the pannexin family of gap junction proteins was studied in the retina by in situ hybridization and qRT-PCR [2].
• METHODS: Panx1 and Panx2 expression was studied by in situ hybridization and quantitative RT-PCR [4].

References