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Gene Review

PANX1  -  pannexin 1

Homo sapiens

Synonyms: MRS1, PX1, Pannexin-1, UNQ2529, UNQ2529/PRO6028
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Disease relevance of PANX1

  • Pannexin also may participate in pathological reactions of the neural cells, including their damage after ischemia and subsequent cell death [1].

High impact information on PANX1

  • Pannexin 1 in erythrocytes: function without a gap [2].
  • In paired oocytes, Px1, alone and in combination with Px2, induces the formation of intercellular channels [3].
  • In many neuronal cell populations, including hippocampus, olfactory bulb, cortex and cerebellum, there is coexpression of both pannexins, whereas in other brain regions, e.g., white matter, only Px1-positive cells were found [3].
  • Pannexin-1 Couples to Maitotoxin- and Nigericin-induced Interleukin-1beta Release through a Dye Uptake-independent Pathway [4].
  • Pannexin-1 is a recently identified membrane protein that can act as a nonselective pore permeable to dyes such as ethidium when ectopically expressed [4].

Biological context of PANX1


Anatomical context of PANX1


Associations of PANX1 with chemical compounds


Analytical, diagnostic and therapeutic context of PANX1


  1. What is hidden in the pannexin treasure trove: the sneak peek and the guesswork. Litvin, O., Tiunova, A., Connell-Alberts, Y., Panchin, Y., Baranova, A. J. Cell. Mol. Med. (2006) [Pubmed]
  2. Pannexin 1 in erythrocytes: function without a gap. Locovei, S., Bao, L., Dahl, G. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  3. Pannexins, a family of gap junction proteins expressed in brain. Bruzzone, R., Hormuzdi, S.G., Barbe, M.T., Herb, A., Monyer, H. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  4. Pannexin-1 Couples to Maitotoxin- and Nigericin-induced Interleukin-1beta Release through a Dye Uptake-independent Pathway. Pelegrin, P., Surprenant, A. J. Biol. Chem. (2007) [Pubmed]
  5. The mammalian pannexin family is homologous to the invertebrate innexin gap junction proteins. Baranova, A., Ivanov, D., Petrash, N., Pestova, A., Skoblov, M., Kelmanson, I., Shagin, D., Nazarenko, S., Geraymovych, E., Litvin, O., Tiunova, A., Born, T.L., Usman, N., Staroverov, D., Lukyanov, S., Panchin, Y. Genomics (2004) [Pubmed]
  6. Molecular characterization of pannexins in the lens. Dvoriantchikova, G., Ivanov, D., Pestova, A., Shestopalov, V. Mol. Vis. (2006) [Pubmed]
  7. Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium. Locovei, S., Wang, J., Dahl, G. FEBS Lett. (2006) [Pubmed]
  8. Expression of pannexin family of proteins in the retina. Dvoriantchikova, G., Ivanov, D., Panchin, Y., Shestopalov, V.I. FEBS Lett. (2006) [Pubmed]
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