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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

LGALS14  -  lectin, galactoside-binding, soluble, 14

Homo sapiens

Synonyms: CLC2, Charcot-Leyden crystal protein 2, Gal-14, Galectin-14, PPL13, ...
 
 
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High impact information on LGALS14

  • Differential paired-pulse responses between the CA1 region and the dentate gyrus are related to altered CLC-2 immunoreactivity in the pilocarpine-induced rat epilepsy model [1].
  • Unlike VGAT, CLC-2 immunoreactivity was markedly reduced in the hippocampus during epileptogenic periods and was re-enhanced only in the dentate gyrus after recurrent seizure onset [1].
  • A novel human galectin cDNA (PPL13) was isolated by screening a human 18-week fetal brain library [2].
  • COS-7 cells transfected with cDNA encoding human PPL13 sequestered the protein in nuclei although it lacked any known nuclear localization signal [2].
 

Anatomical context of LGALS14

  • Linear regression analysis showed an inverse proportional relationship between alterations in CLC-2 immunoreactivity and changes in normalized population spike amplitude ratio within the CA1 region and the dentate gyrus [1].

References

  1. Differential paired-pulse responses between the CA1 region and the dentate gyrus are related to altered CLC-2 immunoreactivity in the pilocarpine-induced rat epilepsy model. Kwak, S.E., Kim, J.E., Kim, D.S., Won, M.H., Lee, H.J., Choi, S.Y., Kwon, O.S., Kim, J.S., Kang, T.C. Brain Res. (2006) [Pubmed]
  2. Cloning and expression of a novel human galectin cDNA, predominantly expressed in placenta(1). Yang, Q.S., Ying, K., Yuan, H.L., Chen, J.Z., Meng, X.F., Wang, Z., Xie, Y., Mao, Y.M. Biochim. Biophys. Acta (2002) [Pubmed]
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