The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

Links

 

Gene Review

UBQLN4  -  ubiquilin 4

Homo sapiens

Synonyms: A1U, A1Up, Ataxin-1 interacting ubiquitin-like protein, Ataxin-1 ubiquitin-like-interacting protein A1U, C1orf6, ...
 
 
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.
 

High impact information on UBQLN4

  • These results suggest that A1Up may link ataxin-1 with the chaperone and ubiquitin-proteasome pathways [1].
  • A1Up localized to the nucleus and cytoplasm of transfected COS-1 cells [1].
  • We also demonstrate that the cDNA sequence shown as part of the LIS2 gene and marking its chromosome 2 specificity belongs to the 3' untranslated region of a different gene (C1orf6) that we mapped to 1q21 by FISH analysis [2].
 

Anatomical context of UBQLN4

  • Expression analyses demonstrated that A1U mRNA is widely expressed as an approximately 4.0 kb transcript and is present in Purkinje cells, the primary site of SCA1 cerebellar pathology [1].
 

Analytical, diagnostic and therapeutic context of UBQLN4

  • Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting signal sequences [3].

References

  1. Identification and characterization of an ataxin-1-interacting protein: A1Up, a ubiquitin-like nuclear protein. Davidson, J.D., Riley, B., Burright, E.N., Duvick, L.A., Zoghbi, H.Y., Orr, H.T. Hum. Mol. Genet. (2000) [Pubmed]
  2. Identification of two paralogous regions mapping to the short and long arms of human chromosome 2 comprising LIS1 pseudogenes. Fogli, A., Giglio, S., Arrigo, G., Lo Nigro, C., Zollo, M., Viggiano, L., Rocchi, M., Archidiacono, N., Zuffardi, O., Carrozzo, R. Cytogenet. Cell Genet. (1999) [Pubmed]
  3. Molecular cloning of a novel ubiquitin-like protein, UBIN, that binds to ER targeting signal sequences. Matsuda, M., Koide, T., Yorihuzi, T., Hosokawa, N., Nagata, K. Biochem. Biophys. Res. Commun. (2001) [Pubmed]
 
WikiGenes - Universities