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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

THOC2  -  THO complex 2

Homo sapiens

Synonyms: CXorf3, THO complex subunit 2, THO2, Tho2, dJ506G2.1, ...
 
 
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High impact information on THOC2

  • Hybrid clones derived from a nitrosocarbaryl-transformed Balb/3T3 cell line, Clone H, and a nontransformed cell line THO2 resemble the transformed parent in the clone morphology, higher saturation density, colony formation in medium with reduced serum concentration, growth in agarose and ability to form clones on Balb/3T3 monolayer [1].
  • Hybrid clones derived from THO2 and SV40-transformed cells show dominant expression of the transformed phenotype with respect to multilayered arrangement of cells and ability to synthesize DNA in 1% calf-serum medium [2].
  • The codominant expression of ouabain resistance and inability of THO2 to utilize exogenous hypoxanthine in the presence of aminopterin allows isolation of somatic cell hybrids involving THO2 and any ouabain-sensitive, hypoxanthine phosphoribosyltransferase-positive cell line [2].
  • A cell line, THO2, was isolated from Balb/3T3 clone A31 after sequential nitrosoguanidine treatments and selection for resistance to 6-thioguanine and ouabain [2].

References

  1. Expression of transformation in cell hybrids. II. Nonsuppression of the transformed phenotype in hybrids between a chemically transformed and nontransformed derivatives of Balb/3T3. Jha, K.K., Cacciapuoti, J., Ozer, H.L. J. Cell. Physiol. (1978) [Pubmed]
  2. Expression of transformation in cell hybrids. I. Isolation and application of density-inhibited Balb/3T3 cells deficient in hypoxanthine phosphoribosyltransferase and resistant to ouabain. Jha, K.K., Ozer, H.L. Somatic Cell Genet. (1976) [Pubmed]
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