Chemical Compound Review:
aminopterin 2-[[4-[(2,4-diaminopteridin- 6...
Synonyms:
SureCN8887, AG-K-02546, AG-L-58337, SureCN8161477, BSPBio_002972, ...
- Reduced forms of aminopterin and methotrexate in L1210 lymphoma. Makulu, D.R., Fölsch, E. J. Natl. Cancer Inst. (1977)
- Polycyclic aromatic hydrocarbon mutagenesis of human epidermal keratinocytes in culture. Allen-Hoffmann, B.L., Rheinwald, J.G. Proc. Natl. Acad. Sci. U.S.A. (1984)
- Rabbit monoclonal antibodies: generating a fusion partner to produce rabbit-rabbit hybridomas. Spieker-Polet, H., Sethupathi, P., Yam, P.C., Knight, K.L. Proc. Natl. Acad. Sci. U.S.A. (1995)
- Structural design, biochemical properties, and evidence for improved therapeutic activity of 5-alkyl derivatives of 5-deazaaminopterin and 5-deazamethotrexate compared to methotrexate in murine tumor models. Sirotnak, F.M., Schmid, F.A., Otter, G.M., Piper, J.R., Montgomery, J.A. Cancer Res. (1988)
- Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro. Samuels, L.L., Moccio, D.M., Sirotnak, F.M. Cancer Res. (1985)
- Pseudoaminopterin syndrome. Verloes, A., Bricteux, G., Koulischer, L. Am. J. Med. Genet. (1993)
- Maternal toxicity in humans and animals: effects on fetal development and criteria for detection. Khera, K.S. Teratog., Carcinog. Mutagen. (1987)
- Generation of functional human T cell hybrids. Irigoyen, O., Rizzolo, P.V., Thomas, Y., Rogozinski, L., Chess, L. J. Exp. Med. (1981)
- Monoclonal lupus autoantibody secretion by human-human hybridomas. Selection of hybrids by conventional and novel techniques. Littman, B.H., Muchmore, A.V., Steinberg, A.D., Greene, W.C. J. Clin. Invest. (1983)
- Import of a DHFR hybrid protein into glycosomes in vivo is not inhibited by the folate-analogue aminopterin. Häusler, T., Stierhof, Y.D., Wirtz, E., Clayton, C. J. Cell Biol. (1996)
- Chromosomes of older humans are more prone to aminopterine-induced breakage. Esposito, D., Fassina, G., Szabo, P., De Angelis, P., Rodgers, L., Weksler, M., Siniscalco, M. Proc. Natl. Acad. Sci. U.S.A. (1989)
- Drug-induced hepatitis associated with anticytoplasmic organelle autoantibodies. Homberg, J.C., Abuaf, N., Helmy-Khalil, S., Biour, M., Poupon, R., Islam, S., Darnis, F., Levy, V.G., Opolon, P., Beaugrand, M. Hepatology (1985)
- Proton magnetic resonance studies on Escherichia coli dihydrofolate reductase. Assignment of histidine C-2 protons in binary complexes with folates on the basis of the crystal structure with methotrexate and on chemical modifications. Poe, M., Hoogsteen, K., Matthews, D.A. J. Biol. Chem. (1979)
- Production and expression of dTMP-enriched DNA of bacteriophage SP15. Casella, E., Markewych, O., Dosmar, M., Witmer, H. J. Virol. (1978)
- Synthesis of 5-chloro-5,8-dideaza analogues of folic acid and aminopterin targeted for colon adenocarcinoma. Hynes, J.B., Kumar, A., Tomazic, A., Washtien, W.L. J. Med. Chem. (1987)
- Establishment and characterization of human T hybrid cells secreting immunoregulatory molecules. Okada, M., Yoshimura, N., Kaieda, T., Yamamura, Y., Kishimoto, T. Proc. Natl. Acad. Sci. U.S.A. (1981)
- Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase. Mulligan, R.C., Berg, P. Proc. Natl. Acad. Sci. U.S.A. (1981)
- Increased dexamethasone resistance of cystic fibrosis fibroblasts. Epstein, J., Breslow, J.L., Davidson, R.L. Proc. Natl. Acad. Sci. U.S.A. (1977)
- DNA-mediated cotransfer of excision repair capacity and drug resistance into chinese hamster ovary mutant cell line UV-135. MacInnes, M.A., Bingham, J.M., Thompson, L.H., Strniste, G.F. Mol. Cell. Biol. (1984)
- Xenogeneic gene expression in chimeric mice derived from rat--mouse hybrid cells. Illmensee, K., Croce, C.M. Proc. Natl. Acad. Sci. U.S.A. (1979)
- Further evidence for a basis of selective activity and relative responsiveness during antifolate therapy of murine tumors. Sirotnak, F.M., Donsback, R.C. Cancer Res. (1975)
- Differing specificities for 4-aminofolate analogues of folylpolyglutamyl synthetase from tumors and proliferative intestinal epithelium of the mouse with significance for selective antitumor action. Rumberger, B.G., Barrueco, J.R., Sirotnak, F.M. Cancer Res. (1990)
- Neuronal traits of clonal cell lines derived by fusion of dorsal root ganglia neurons with neuroblastoma cells. Platika, D., Boulos, M.H., Baizer, L., Fishman, M.C. Proc. Natl. Acad. Sci. U.S.A. (1985)
- Interspecies Lewis lung carcinoma x Chinese hamster ovary hybrids as protective agents against Lewis lung carcinoma tumor growth. Wolfman, J., Baumal, R., Marks, A. Cancer Res. (1985)
- Increased survival after treatments with anticancer agents of Chinese hamster cells expressing the human Mr 27,000 heat shock protein. Huot, J., Roy, G., Lambert, H., Chrétien, P., Landry, J. Cancer Res. (1991)
- Ecto-5'-nucleotidase can provide the total purine requirements of mitogen-stimulated human T cells and rapidly dividing human B lymphoblastoid cells. Thompson, L.F. J. Immunol. (1985)
- Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway. Pellegrini, S., John, J., Shearer, M., Kerr, I.M., Stark, G.R. Mol. Cell. Biol. (1989)
- The Drosophila wing differentiation factor vestigial-scalloped is required for cell proliferation and cell survival at the dorso-ventral boundary of the wing imaginal disc. Delanoue, R., Legent, K., Godefroy, N., Flagiello, D., Dutriaux, A., Vaudin, P., Becker, J.L., Silber, J. Cell Death Differ. (2004)
- Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines. McCloskey, D.E., McGuire, J.J., Russell, C.A., Rowan, B.G., Bertino, J.R., Pizzorno, G., Mini, E. J. Biol. Chem. (1991)
- Carrier- and receptor-mediated transport of folate antagonists targeting folate-dependent enzymes: correlates of molecular-structure and biological activity. Westerhof, G.R., Schornagel, J.H., Kathmann, I., Jackman, A.L., Rosowsky, A., Forsch, R.A., Hynes, J.B., Boyle, F.T., Peters, G.J., Pinedo, H.M. Mol. Pharmacol. (1995)
- Inhibition of murine thymidylate synthase and human dihydrofolate reductase by 5,8-dideaza analogues of folic acid and aminopterin. Hynes, J.B., Patil, S.A., Tomazic, A., Kumar, A., Pathak, A., Tan, X.H., Li, X.Q., Ratnam, M., Delcamp, T.J., Freisheim, J.H. J. Med. Chem. (1988)
- T4 phage-coded dihydrofolate reductase. Subunit composition and cloning of its structural gene. Purohit, S., Bestwick, R.K., Lasser, G.W., Rogers, C.M., Mathews, C.K. J. Biol. Chem. (1981)
- Isolation of human-mouse somatic cell hybrids producing human prolactin: dominant expression of hormone secretion and regulation. Melmed, S. J. Clin. Endocrinol. Metab. (1983)
- Synthesis and biological activity of an acyclic analogue of 5,6,7,8-tetrahydrofolic acid, N-[4-[[3-(2,4-diamino-1,6-dihydro-6-oxo-5- pyrimidinyl)propyl]amino]-benzoyl]-L-glutamic acid. Kelley, J.L., McLean, E.W., Cohn, N.K., Edelstein, M.P., Duch, D.S., Smith, G.K., Hanlon, M.H., Ferone, R. J. Med. Chem. (1990)
- A pgk::hprt fusion as a selectable marker for targeting of genes in mouse embryonic stem cells: disruption of the T-cell receptor delta-chain-encoding gene. van der Lugt, N., Maandag, E.R., te Riele, H., Laird, P.W., Berns, A. Gene (1991)
- Ionic excitation of a clone of mouse neuroblastoma. Tuttle, J.B., Richelson, E. Brain Res. (1975)