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Chemical Compound Review

Nitrosoguanidines     2-nitrosoguanidine

Synonyms: WLN: ONMYZUM, CHEMBL447467, CCRIS 2194, AG-G-55196, NSC-33670, ...
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Disease relevance of NSC33670


High impact information on NSC33670


Chemical compound and disease context of NSC33670


Biological context of NSC33670


Anatomical context of NSC33670


Associations of NSC33670 with other chemical compounds


Gene context of NSC33670

  • We conclude that errors in the recA-dependent repair of induced DNA damage (after 4NQO, MTC, UV and X-rays) or errors in replication enhanced by damage to the replication system or to the template strands (after NTG, EMS, and HA) give rise to deletions as well as to base changes [28].
  • A novel mutant isolate of Saccharomyces cerevisiae, sensitive to photoactivated mono- and bi-functional psoralens, to UV at 254 nm (UVC), and to nitrosoguanidine, was found to complement the photoactivated psoralen-sensitivity phenotype conferred by the pso1- pso7 mutations and was therefore named pso8-1 [29].
  • While there was none for HYR to nitrosoguanidine, and other low glutathione-related phenotypes, some other phenotypic characteristics of pso3-1, e.g. UVC sensitivity and UVC-induced mutability were restored to a wild-type level [30].
  • Overexpression of the SNQ3/YAP1 gene confers hyper-resistance to nitrosoguanidine in Saccharomyces cerevisiae via a glutathione-independent mechanism [31].
  • Escherichia coli WC196, which was obtained from the strain W3110 by nitrosoguanidine mutagenesis as an overproducer of lysine, produced approximately twenty times more cadaverine than did W3110, and had a twenty fold higher level of rpoS gene product, sigma38, than in W3110 [32].

Analytical, diagnostic and therapeutic context of NSC33670


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