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Chemical Compound Review:

Nitroso-nac naphthalen-1-yl N-methyl-N-nitroso-carbamate

Synonyms: CCRIS 1217, AG-G-40484, AC1L2MGK, LS-50304, CTK5C0843, ...

Chan, H.H. et al., Quarles, J.M. et al., Jha, K.K. et al., Kimball, R.F. et al., Beraud, M. et al., et al.

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Disease relevance of Nitrosocarbaryl

Thus, it appears that nitrosocarbaryl can transform BALB/3T3 cells to tumorigenic cells with altered biological properties but without complete activation of RNA tumor viruses in the transformed cells [1].
N-Nitrosocarbaryl-induced mutagenesis in Haemophilus influenzae strains deficient in repair and recombination [2].
N-Nitrosocarbaryl (N-methyl-1-naphthyl N-nitrosocarbamate) was intraperitoneally administered to male and female rats on four consecutive days at the following doses: 6.25 mg, 12.5 mg, 25 mg and 50 mg/kg body weight/day in olive oil solution; the controls received just the oil [3].

High impact information on Nitrosocarbaryl

Effects of nitrosocarbaryl on BALB/3T3 cells [1].
Nitrosocarbaryl, but not carbaryl, caused transformation of the BALB/3T3 fibroblasts, but neither chemical induced the complete expression of endogenous murine leukemia virus [1].
Hybrid clones derived from a nitrosocarbaryl-transformed Balb/3T3 cell line, Clone H, and a nontransformed cell line THO2 resemble the transformed parent in the clone morphology, higher saturation density, colony formation in medium with reduced serum concentration, growth in agarose and ability to form clones on Balb/3T3 monolayer [4].
Haemophilus influenzae Rd and its derivatives are mutated either not at all or to only a very small extent by ultraviolet (UV) radiation, X-rays, methyl methanesulfonate, and nitrogen mustard, though they are readily mutated by such agents as N-methyl-N'-nitro-N-nitrosoguanidine, ethyl methanesulfonate, and nitrosocarbaryl [5].
Lipid peroxidation in rat liver microsomes: influence of carcinogenic N-nitrosocarbaryl [6].

Biological context of Nitrosocarbaryl

Six alkylarylnitrosoureas were checked for induction of chromosome aberrations and SCEs in Chinese hamster V79-E cells and compared with MNU, ENU and nitrosocarbaryl [7].

Anatomical context of Nitrosocarbaryl

In microsomes, nitrosocarbaryl showed a significant (P less than 0.001) inhibition of aryl hydrocarbon hydroxylase and aminopyrine N-demethylase as compared with the control when the concentration of nitrosocarbaryl added was above 1 X 10(-5) M [8].

Gene context of Nitrosocarbaryl

Nitrosocarbaryl inhibited epoxide hydrolase activity gradually up to 18% at the range of concentration studied (1.3 X 10(-3) M - 1.2 X 10(-2) M) and showed a significant (P less than 0.001) inhibition at the concentration of 1.2 X 10(-2) M [8].

Analytical, diagnostic and therapeutic context of Nitrosocarbaryl

Mutagenesis was studied in repair- and recombination-deficient strains of Haemophilus influenzae after treatment with N-nitrosocarbaryl (NC) [2].
Distribution of radioactivity following oral administration of carcinogenic 14CH3-labelled nitrosocarbaryl in the rat [9].

References

Effects of nitrosocarbaryl on BALB/3T3 cells. Quarles, J.M., Tennant, R.W. Cancer Res. (1975) [Pubmed]
N-Nitrosocarbaryl-induced mutagenesis in Haemophilus influenzae strains deficient in repair and recombination. Beattie, K.L. Mutat. Res. (1975) [Pubmed]
Inhibition of two rat hepatic microsomal drug-metabolizing enzymes by a carcinogenic N-nitrosated pesticide: N-nitrosocarbaryl. Beraud, M., Gaillard, S., Derache, R. Chem. Biol. Interact. (1980) [Pubmed]
Expression of transformation in cell hybrids. II. Nonsuppression of the transformed phenotype in hybrids between a chemically transformed and nontransformed derivatives of Balb/3T3. Jha, K.K., Cacciapuoti, J., Ozer, H.L. J. Cell. Physiol. (1978) [Pubmed]
Evidence that UV-inducible error-prone repair is absent in Haemophilus influenzae Rd, with a discussion of the relation to error-prone repair of alkylating-agent damage. Kimball, R.F., Boling, M.E., Perdue, S.W. Mutat. Res. (1977) [Pubmed]
Lipid peroxidation in rat liver microsomes: influence of carcinogenic N-nitrosocarbaryl. Beraud, M., Forgue, M.F., Pipy, B., Didier, A., Carre, P. Toxicology (1989) [Pubmed]
Clastogenicity and aberration kinetics of some alkylarylnitrosoureas in Chinese hamster V79-E cells. Thust, R., Mendel, J., Schwarz, H., Warzok, R. IARC Sci. Publ. (1980) [Pubmed]
Comparison of nitrosocarbaryl and carbaryl: in vitro effects on hepatic microsomal aryl hydrocarbon hydroxylase, aminopyrine N-demethylase, epoxide hydrolase and cytosolic glutathione-S-transferase. Chan, H.H., Buhler, D.R. Proc. Natl. Sci. Counc. Repub. China B (1984) [Pubmed]
Distribution of radioactivity following oral administration of carcinogenic 14CH3-labelled nitrosocarbaryl in the rat. Beraud, M., Gaillard, D., Pipy, B., Derache, R. Cancer Lett. (1981) [Pubmed]

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