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Gene Review

TRIM5  -  tripartite motif containing 5

Macaca mulatta

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Disease relevance of TRIM5

  • By contrast, similar chimeras containing the components of TRIM21, a slightly more distant relative of TRIM5, did not restrict HIV-1 infection [1].
  • The primate TRIM5 proteins constitute a class of restriction factors that prevent host cell infection by retroviruses from different species [2].
  • The TRIM5 proteins act early after virion entry and prevent viral reverse transcription products from accumulating [2].


  1. Functional replacement of the RING, B-box 2, and coiled-coil domains of tripartite motif 5alpha (TRIM5alpha) by heterologous TRIM domains. Li, X., Li, Y., Stremlau, M., Yuan, W., Song, B., Perron, M., Sodroski, J. J. Virol. (2006) [Pubmed]
  2. Proteasome Inhibition Reveals that a Functional Preintegration Complex Intermediate Can Be Generated during Restriction by Diverse TRIM5 Proteins. Anderson, J.L., Campbell, E.M., Wu, X., Vandegraaff, N., Engelman, A., Hope, T.J. J. Virol. (2006) [Pubmed]
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