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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

USP31  -  ubiquitin specific peptidase 31

Homo sapiens

Synonyms: Deubiquitinating enzyme 31, KIAA1203, Ubiquitin carboxyl-terminal hydrolase 31, Ubiquitin thioesterase 31, Ubiquitin-specific-processing protease 31
 
 
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High impact information on USP31

  • Our data support a role for USP31 in the regulation of NF-kappaB activation by members of the TNF receptor superfamily [1].
  • A yeast two-hybrid screen of a human cDNA library identified a ubiquitin specific protease homologue (USP31) as a TRAF2-interacting protein [1].
  • USP31 and USP31S1 share a common amino terminal region with homology to the catalytic region of known deubiquitinating enzymes [1].
  • Northern blot analysis revealed a single USP31 transcript of approximately 4 kb, which was primarily expressed in the testis and lung [2].

References

  1. Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-kappaB. Tzimas, C., Michailidou, G., Arsenakis, M., Kieff, E., Mosialos, G., Hatzivassiliou, E.G. Cell. Signal. (2006) [Pubmed]
  2. Identification of the human ubiquitin specific protease 31 (USP31) gene: structure, sequence and expression analysis. Lockhart, P.J., Hulihan, M., Lincoln, S., Hussey, J., Skipper, L., Bisceglio, G., Wilkes, K., Farrer, M.J. DNA Seq. (2004) [Pubmed]
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