Disease relevance of PDZD4

• Identification of PDZK4, a novel human gene with PDZ domains, that is upregulated in synovial sarcomas [1].

High impact information on PDZD4

• Immunocytochemical staining of transfected COS7 cells showed that the PDZK4 gene product localized mainly under the plasma membrane [1].
• Using a whole-cell assay and nuclear and cytosolic radiobinding experiments with [3H]estradiol as tracer, we have found that SK-LU1, SW900, ChaGo-K-1, H441, H661, and A549 cells, as well as primary tumors, bind estrogen specifically [2].
• In this case, a slender woman received acupuncture from a fully trained medical acupuncturist including needling of the points LU1 in the subacromial region and BL13, which is a paravertebral point at the level of the spinous process of the third thoracic vertebra [3].
• We herein present the entire sequences of 100 cDNA clones of unknown human genes, named KIAA1444 to KIAA1543, from two sets of size-fractionated human adult and fetal brain cDNA libraries [4].

Analytical, diagnostic and therapeutic context of PDZD4

• On Northern blots of normal human tissues, the PDZK4 transcript was expressed only in fetal brain [1].

References