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Gene Review

PDZD4  -  PDZ domain containing 4

Homo sapiens

Synonyms: FLJ34125, KIAA1444, LU1, PDZ domain-containing RING finger protein 4-like protein, PDZ domain-containing protein 4, ...
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Disease relevance of PDZD4


High impact information on PDZD4

  • Immunocytochemical staining of transfected COS7 cells showed that the PDZK4 gene product localized mainly under the plasma membrane [1].
  • Using a whole-cell assay and nuclear and cytosolic radiobinding experiments with [3H]estradiol as tracer, we have found that SK-LU1, SW900, ChaGo-K-1, H441, H661, and A549 cells, as well as primary tumors, bind estrogen specifically [2].
  • In this case, a slender woman received acupuncture from a fully trained medical acupuncturist including needling of the points LU1 in the subacromial region and BL13, which is a paravertebral point at the level of the spinous process of the third thoracic vertebra [3].
  • We herein present the entire sequences of 100 cDNA clones of unknown human genes, named KIAA1444 to KIAA1543, from two sets of size-fractionated human adult and fetal brain cDNA libraries [4].

Analytical, diagnostic and therapeutic context of PDZD4


  1. Identification of PDZK4, a novel human gene with PDZ domains, that is upregulated in synovial sarcomas. Nagayama, S., Iiizumi, M., Katagiri, T., Toguchida, J., Nakamura, Y. Oncogene (2004) [Pubmed]
  2. Interaction with type II estrogen binding sites and antiproliferative activity of tamoxifen and quercetin in human non-small-cell lung cancer. Caltagirone, S., Ranelletti, F.O., Rinelli, A., Maggiano, N., Colasante, A., Musiani, P., Aiello, F.B., Piantelli, M. Am. J. Respir. Cell Mol. Biol. (1997) [Pubmed]
  3. Case report of tension pneumothorax related to acupuncture. Peuker, E. Acupuncture in medicine : journal of the British Medical Acupuncture Society. (2004) [Pubmed]
  4. Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase, T., Kikuno, R., Ishikawa, K., Hirosawa, M., Ohara, O. DNA Res. (2000) [Pubmed]
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