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MeSH Review

Sarcoma, Synovial

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Disease relevance of Sarcoma, Synovial


High impact information on Sarcoma, Synovial


Chemical compound and disease context of Sarcoma, Synovial

  • Synovial sarcomas were responsive to ifosfamide plus doxorubicin, especially among patients younger than 40 years of age [10].
  • Our results indicate that this molecular assay can be applied to archival formalin-fixed, paraffin-embedded tumor tissues as a feasible and reliable molecular technique for the diagnosis of synovial sarcoma [11].
  • For alkaline phosphatase and adenosine triphosphatase particularly, positive cells and negative cells coexisted, as in the large plump cells of synovial sarcoma [12].
  • Analysis of two contigs, C1- and C4, using FISH established that in four of six synovial sarcomas examined the breakpoint occurs between these two contigs: C1 lies distal to the break-point while C4 is proximal [13].
  • We also found a loss of imprinting (LOI) for Igf2 in a limited number of primary synovial sarcomas despite demethylation of CpG dinucleotides critical for maintaining imprinting [14].
  • Ifosfamide-based chemotherapy was associated with an improved DSS in adult patients with high-risk, primary, extremity, synovial sarcoma and should be considered in the treatment of such patients [15].

Biological context of Sarcoma, Synovial


Anatomical context of Sarcoma, Synovial


Gene context of Sarcoma, Synovial


Analytical, diagnostic and therapeutic context of Sarcoma, Synovial


  1. elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints. Rao, V.N., Huebner, K., Isobe, M., ar-Rushdi, A., Croce, C.M., Reddy, E.S. Science (1989) [Pubmed]
  2. Translocations in solid tumours. Cooper, C.S. Curr. Opin. Genet. Dev. (1996) [Pubmed]
  3. Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology. Nielsen, T.O., Hsu, F.D., O'Connell, J.X., Gilks, C.B., Sorensen, P.H., Linn, S., West, R.B., Liu, C.L., Botstein, D., Brown, P.O., van de Rijn, M. Am. J. Pathol. (2003) [Pubmed]
  4. Expression of fatty acid synthase as a prognostic indicator in soft tissue sarcomas. Takahiro, T., Shinichi, K., Toshimitsu, S. Clin. Cancer Res. (2003) [Pubmed]
  5. Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasms. Perry, A., Kunz, S.N., Fuller, C.E., Banerjee, R., Marley, E.F., Liapis, H., Watson, M.A., Gutmann, D.H. J. Neuropathol. Exp. Neurol. (2002) [Pubmed]
  6. p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion. Eid, J.E., Kung, A.L., Scully, R., Livingston, D.M. Cell (2000) [Pubmed]
  7. SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma. Kawai, A., Woodruff, J., Healey, J.H., Brennan, M.F., Antonescu, C.R., Ladanyi, M. N. Engl. J. Med. (1998) [Pubmed]
  8. Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. Clark, J., Rocques, P.J., Crew, A.J., Gill, S., Shipley, J., Chan, A.M., Gusterson, B.A., Cooper, C.S. Nat. Genet. (1994) [Pubmed]
  9. Re: A novel fusion gene, SYT-SSX4, in synovial sarcoma. Agus, V., Tamborini, E., Mezzelani, A., Pierotti, M.A., Pilotti, S. J. Natl. Cancer Inst. (2001) [Pubmed]
  10. Randomized comparison of doxorubicin alone versus ifosfamide plus doxorubicin or mitomycin, doxorubicin, and cisplatin against advanced soft tissue sarcomas. Edmonson, J.H., Ryan, L.M., Blum, R.H., Brooks, J.S., Shiraki, M., Frytak, S., Parkinson, D.R. J. Clin. Oncol. (1993) [Pubmed]
  11. Detection of SYT-SSX fusion transcripts in synovial sarcoma by reverse transcription-polymerase chain reaction using archival paraffin-embedded tissues. Tsuji, S., Hisaoka, M., Morimitsu, Y., Hashimoto, H., Shimajiri, S., Komiya, S., Ushijima, M., Nakamura, T. Am. J. Pathol. (1998) [Pubmed]
  12. Cellular differentiation of epithelioid sarcoma. An electron-microscopic, enzyme-histochemical, and immunohistochemical study. Mukai, M., Torikata, C., Iri, H., Hanaoka, H., Kawai, T., Yakumaru, K., Shimoda, T., Mikata, A., Kageyama, K. Am. J. Pathol. (1985) [Pubmed]
  13. The t(X;18)(p11.2;q11.2) translocation found in human synovial sarcomas involves two distinct loci on the X chromosome. Shipley, J.M., Clark, J., Crew, A.J., Birdsall, S., Rocques, P.J., Gill, S., Chelly, J., Monaco, A.P., Abe, S., Gusterson, B.A. Oncogene (1994) [Pubmed]
  14. IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1. Sun, Y., Gao, D., Liu, Y., Huang, J., Lessnick, S., Tanaka, S. Oncogene (2006) [Pubmed]
  15. Chemotherapy is associated with improved survival in adult patients with primary extremity synovial sarcoma. Eilber, F.C., Brennan, M.F., Eilber, F.R., Eckardt, J.J., Grobmyer, S.R., Riedel, E., Forscher, C., Maki, R.G., Singer, S. Ann. Surg. (2007) [Pubmed]
  16. Immunomic analysis of human sarcoma. Lee, S.Y., Obata, Y., Yoshida, M., Stockert, E., Williamson, B., Jungbluth, A.A., Chen, Y.T., Old, L.J., Scanlan, M.J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  17. Expression of insulin-like growth factor-1 receptor in synovial sarcoma: association with an aggressive phenotype. Xie, Y., Skytting, B., Nilsson, G., Brodin, B., Larsson, O. Cancer Res. (1999) [Pubmed]
  18. The SYT-SSX1 variant of synovial sarcoma is associated with a high rate of tumor cell proliferation and poor clinical outcome. Nilsson, G., Skytting, B., Xie, Y., Brodin, B., Perfekt, R., Mandahl, N., Lundeberg, J., Uhlén, M., Larsson, O. Cancer Res. (1999) [Pubmed]
  19. SYT-SSX is critical for cyclin D1 expression in synovial sarcoma cells: a gain of function of the t(X;18)(p11.2;q11.2) translocation. Xie, Y., Skytting, B., Nilsson, G., Gasbarri, A., Haslam, K., Bartolazzi, A., Brodin, B., Mandahl, N., Larsson, O. Cancer Res. (2002) [Pubmed]
  20. Interphase fluorescence in situ hybridization and reverse transcription polymerase chain reaction as a diagnostic aid for synovial sarcoma. Shipley, J., Crew, J., Birdsall, S., Gill, S., Clark, J., Fisher, C., Kelsey, A., Nojima, T., Sonobe, H., Cooper, C., Gusterson, B. Am. J. Pathol. (1996) [Pubmed]
  21. Usefulness of cytokeratin subsets for distinguishing monophasic synovial sarcoma from malignant peripheral nerve sheath tumor. Smith, T.A., Machen, S.K., Fisher, C., Goldblum, J.R. Am. J. Clin. Pathol. (1999) [Pubmed]
  22. D2-40 and podoplanin are highly specific and sensitive immunohistochemical markers of epithelioid malignant mesothelioma. Ordóñez, N.G. Hum. Pathol. (2005) [Pubmed]
  23. Primary monophasic synovial sarcoma of the pleura: five cases confirmed by the presence of SYT-SSX fusion transcript. Aubry, M.C., Bridge, J.A., Wickert, R., Tazelaar, H.D. Am. J. Surg. Pathol. (2001) [Pubmed]
  24. Platelet-derived growth factor receptor (beta-subunit) immunoreactivity in soft tissue tumors. Palman, C., Bowen-Pope, D.F., Brooks, J.J. Lab. Invest. (1992) [Pubmed]
  25. SYT-SSX fusion genes in synovial sarcoma of the thorax. Yano, M., Toyooka, S., Tsukuda, K., Dote, H., Morimoto, Y., Ohata, N., Ichimura, K., Aoe, M., Date, H., Shimizu, N. Lung Cancer (2004) [Pubmed]
  26. A novel fusion gene, SYT-SSX4, in synovial sarcoma. Skytting, B., Nilsson, G., Brodin, B., Xie, Y., Lundeberg, J., Uhlén, M., Larsson, O. J. Natl. Cancer Inst. (1999) [Pubmed]
  27. Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. Crew, A.J., Clark, J., Fisher, C., Gill, S., Grimer, R., Chand, A., Shipley, J., Gusterson, B.A., Cooper, C.S. EMBO J. (1995) [Pubmed]
  28. Heterogeneous expression of the SSX cancer/testis antigens in human melanoma lesions and cell lines. dos Santos, N.R., Torensma, R., de Vries, T.J., Schreurs, M.W., de Bruijn, D.R., Kater-Baats, E., Ruiter, D.J., Adema, G.J., van Muijen, G.N., van Kessel, A.G. Cancer Res. (2000) [Pubmed]
  29. The proto-oncoprotein SYT interacts with SYT-interacting protein/co-activator activator (SIP/CoAA), a human nuclear receptor co-activator with similarity to EWS and TLS/FUS family of proteins. Perani, M., Antonson, P., Hamoudi, R., Ingram, C.J., Cooper, C.S., Garrett, M.D., Goodwin, G.H. J. Biol. Chem. (2005) [Pubmed]
  30. Expression profiling of synovial sarcoma by cDNA microarrays: association of ERBB2, IGFBP2, and ELF3 with epithelial differentiation. Allander, S.V., Illei, P.B., Chen, Y., Antonescu, C.R., Bittner, M., Ladanyi, M., Meltzer, P.S. Am. J. Pathol. (2002) [Pubmed]
  31. Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients. Ladanyi, M., Antonescu, C.R., Leung, D.H., Woodruff, J.M., Kawai, A., Healey, J.H., Brennan, M.F., Bridge, J.A., Neff, J.R., Barr, F.G., Goldsmith, J.D., Brooks, J.S., Goldblum, J.R., Ali, S.Z., Shipley, J., Cooper, C.S., Fisher, C., Skytting, B., Larsson, O. Cancer Res. (2002) [Pubmed]
  32. The SYT-SSX1 fusion type of synovial sarcoma is associated with increased expression of cyclin A and D1. A link between t(X;18)(p11.2; q11.2) and the cell cycle machinery. Xie, Y., Skytting, B., Nilsson, G., Grimer, R.J., Mangham, C.D., Fisher, C., Shipley, J., Bjerkehagen, B., Myklebost, O., Larsson, O. Oncogene (2002) [Pubmed]
  33. Clinical impact of molecular and cytogenetic findings in synovial sarcoma. Panagopoulos, I., Mertens, F., Isaksson, M., Limon, J., Gustafson, P., Skytting, B., Akerman, M., Sciot, R., Dal Cin, P., Samson, I., Iliszko, M., Ryoe, J., Dêbiec-Rychter, M., Szadowska, A., Brosjö, O., Larsson, O., Rydholm, A., Mandahl, N. Genes Chromosomes Cancer (2001) [Pubmed]
  34. Prognostic significance of histologic grade and nuclear expression of beta-catenin in synovial sarcoma. Hasegawa, T., Yokoyama, R., Matsuno, Y., Shimoda, T., Hirohashi, S. Hum. Pathol. (2001) [Pubmed]
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