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Gene Review:

KIAA1456 - KIAA1456

Homo sapiens

Synonyms: C8orf79, FLJ36980, TRM9L

Flanagan, J.M. et al.

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Disease relevance of KIAA1456

Despite the rarity of somatic mutations, the expression data suggest that KIAA1456 is still a candidate for the putative 8p colorectal cancer tumor-suppressor gene [1].

High impact information on KIAA1456

FLJ23749 was expressed in all CRC cell lines tested; however, KIAA1456 was downregulated in three cell lines, including SW620, and was restored in the suppressed microcell hybrids [1].
5'aza-2'Deoxycytidine treatment of the downregulated cell lines restored expression of KIAA1456, but bisulfite genomic sequencing did not show a correlation between promoter methylation and expression [1].

Biological context of KIAA1456

Forty percent of the primary tumors showed LOH at this CRCSR locus, and mutation analysis revealed somatic mutations in 1 of 88 primary colorectal tumors for both KIAA1456 and FLJ23749 [1].

References

Mapping of a candidate colorectal cancer tumor-suppressor gene to a 900-kilobase region on the short arm of chromosome 8. Flanagan, J.M., Healey, S., Young, J., Whitehall, V., Trott, D.A., Newbold, R.F., Chenevix-Trench, G. Genes Chromosomes Cancer (2004) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg

KIAA1456	Bos taurus
KIAA1456	Canis lupus familiaris
KIAA1456	Gallus gallus
C8H8orf79	Macaca mulatta
6430573F11Rik	Mus musculus
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RGD1304810	Rattus norvegicus
LOC100488302	Xenopus (Silurana) tropicalis

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