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Gene Review

GBA2  -  glucosidase, beta (bile acid) 2

Homo sapiens

Synonyms: AD035, Beta-glucocerebrosidase 2, Beta-glucosidase 2, DKFZp762K054, Glucosylceramidase 2, ...
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High impact information on GBA2

  • In conclusion, GBA2 plays a role in cellular glucosylceramide metabolism [1].
  • In mice pharmacological inhibition of GBA2 activity is associated with impaired spermatogenesis, a phenomenon also very recently reported for GBA2 knock-out mice (Yildiz, Y., Matern, H., Thompson, B., Allegood, J. C., Warren, R. L., Ramirez, D. M., Hammer, R. E., Hamra, F. K., Matern, S., and Russell, D. W. (2006) J. Clin. Invest. 116, 2985-2994) [1].
  • Expression of GBA2 coincides with increased non-lysosomal glucosylceramidase activity, and GBA2-targeted RNA interference reduces endogenous non-lysosomal glucosylceramidase activity in cells [1].
  • Expressed GBA2 is identical to the native non-lysosomal glucosylceramidase in various enzymatic features such as substrate specificity and inhibitor sensitivity [1].


  1. Identification of the Non-lysosomal Glucosylceramidase as beta-Glucosidase 2. Boot, R.G., Verhoek, M., Donker-Koopman, W., Strijland, A., van Marle, J., Overkleeft, H.S., Wennekes, T., Aerts, J.M. J. Biol. Chem. (2007) [Pubmed]
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