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Gene Review

HES4  -  hes family bHLH transcription factor 4

Homo sapiens

Synonyms: BHLHB42, Class B basic helix-loop-helix protein 42, Hairy and enhancer of split 4, Transcription factor HES-4, bHLH factor Hes4, ...
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High impact information on HES4

  • 5T4-ve and 5T4+ve HES4 and H1 ES cell lines expressed markers representative of neuroectoderm lineages, and we assessed the formation of neural lineages from these phenotypes in serum-containing medium and N2B27 medium [1].
  • To confirm that absence of cell surface 5T4 antigen represents a pluripotent hES cell phenotype, we performed mechanical transfer of either 5T4-ve or 5T4+ve HES4 colonies identified using live cell staining [1].
  • We show that 5T4 antigen is transiently unregulated during HES4 and H1 human ES cell differentiation and its expression correlates with loss of the pluripotent markers OCT-4 and Tra-1-60 and upregulation of transcript markers associated with the three primary germ layers [1].
  • We determined the transcriptome profiles for two proprietary human ES cell lines (HES3 and HES4, ES Cell International), and compared them with murine ES cells and other human tissues [2].


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