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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

HES4  -  hes family bHLH transcription factor 4

Homo sapiens

Synonyms: BHLHB42, Class B basic helix-loop-helix protein 42, Hairy and enhancer of split 4, Transcription factor HES-4, bHLH factor Hes4, ...
 
 
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High impact information on HES4

  • 5T4-ve and 5T4+ve HES4 and H1 ES cell lines expressed markers representative of neuroectoderm lineages, and we assessed the formation of neural lineages from these phenotypes in serum-containing medium and N2B27 medium [1].
  • To confirm that absence of cell surface 5T4 antigen represents a pluripotent hES cell phenotype, we performed mechanical transfer of either 5T4-ve or 5T4+ve HES4 colonies identified using live cell staining [1].
  • We show that 5T4 antigen is transiently unregulated during HES4 and H1 human ES cell differentiation and its expression correlates with loss of the pluripotent markers OCT-4 and Tra-1-60 and upregulation of transcript markers associated with the three primary germ layers [1].
  • We determined the transcriptome profiles for two proprietary human ES cell lines (HES3 and HES4, ES Cell International), and compared them with murine ES cells and other human tissues [2].

References

  1. Cell surface 5T4 antigen is transiently upregulated during early human embryonic stem cell differentiation: effect of 5T4 phenotype on neural lineage formation. Ward, C.M., Eastham, A.M., Stern, P.L. Exp. Cell Res. (2006) [Pubmed]
  2. The transcriptome profile of human embryonic stem cells as defined by SAGE. Richards, M., Tan, S.P., Tan, J.H., Chan, W.K., Bongso, A. Stem Cells (2004) [Pubmed]
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