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Gene Review

HES3  -  hes family bHLH transcription factor 3

Homo sapiens

Synonyms: BHLHB43, Class B basic helix-loop-helix protein 43, Hairy and enhancer of split 3, Transcription factor HES-3, bHLHb43
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High impact information on HES3

  • In the absence of the repressor-type basic helix-loop-helix (bHLH) genes Hes1, Hes3 and Hes5, neural stem cells do not proliferate sufficiently but prematurely differentiate into neurons and become depleted without making the later born cell types such as astrocytes and ependymal cells [1].
  • Identification and characterization of human HES2, HES3, and HES5 genes in silico [2].
  • HES2 and HES3 genes were mapped to human chromosome 1p36.31, while HES5 gene to 1p36.32 [2].
  • We determined the transcriptome profiles for two proprietary human ES cell lines (HES3 and HES4, ES Cell International), and compared them with murine ES cells and other human tissues [3].
  • Here, we identified and characterized human HES2, HES3 and HES5 genes by using bioinformatics [2].

Biological context of HES3

  • HES3 gene, encoding a 186-aa protein, was identified within human genome sequence AL031847.17 [2].


  1. Roles of bHLH genes in neural stem cell differentiation. Kageyama, R., Ohtsuka, T., Hatakeyama, J., Ohsawa, R. Exp. Cell Res. (2005) [Pubmed]
  2. Identification and characterization of human HES2, HES3, and HES5 genes in silico. Katoh, M., Katoh, M. Int. J. Oncol. (2004) [Pubmed]
  3. The transcriptome profile of human embryonic stem cells as defined by SAGE. Richards, M., Tan, S.P., Tan, J.H., Chan, W.K., Bongso, A. Stem Cells (2004) [Pubmed]
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