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Gene Review

CCNB1IP1  -  cyclin B1 interacting protein 1, E3...

Homo sapiens

Synonyms: C14orf18, Cyclin-B1-interacting protein 1, E3 ubiquitin-protein ligase CCNB1IP1, HEI10, Human enhancer of invasion 10
 
 
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Disease relevance of CCNB1IP1

 

High impact information on CCNB1IP1

  • Through two-hybrid screening, the mitotic cyclin B1 and an E2 ubiquitin-conjugating enzyme were isolated as HEI10-interacting proteins [3].
  • The human enhancer of invasion clone 10 (HEI10) protein was identified from a HeLa cell library based on its ability to promote yeast agar invasion and filamentation [3].
  • In vertebrates, the addition of HEI10 inhibits nuclear envelope breakdown and mitotic entry in Xenopus egg extracts [3].
  • In transfected cells, a constitutively open merlin construct affected HEI10 protein integrity [1].
  • The interaction is mediated by the alpha-helical domain in merlin and the coiled-coil domain in HEI10 and requires conformational opening of merlin [1].
 

Biological context of CCNB1IP1

  • A functional association between merlin and HEI10, a cell cycle regulator [1].
  • In the fusion transcript the first two exons of the HMGIC gene, which encode DNA-binding domains, were fused to the 3' portion of the HEI10 gene [2].
 

Physical interactions of CCNB1IP1

 

Analytical, diagnostic and therapeutic context of CCNB1IP1

References

  1. A functional association between merlin and HEI10, a cell cycle regulator. Grönholm, M., Muranen, T., Toby, G.G., Utermark, T., Hanemann, C.O., Golemis, E.A., Carpén, O. Oncogene (2006) [Pubmed]
  2. Fusion of a sequence from HEI10 (14q11) to the HMGIC gene at 12q15 in a uterine leiomyoma. Mine, N., Kurose, K., Konishi, H., Araki, T., Nagai, H., Emi, M. Jpn. J. Cancer Res. (2001) [Pubmed]
  3. A novel RING finger protein, human enhancer of invasion 10, alters mitotic progression through regulation of cyclin B levels. Toby, G.G., Gherraby, W., Coleman, T.R., Golemis, E.A. Mol. Cell. Biol. (2003) [Pubmed]
 
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