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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Leiomyoma


Psychiatry related information on Leiomyoma

  • Based on the evidence available, the panel proposed a number of subgroups of postmenopausal women with vasomotor symptoms in whom tibolone might have added value; these included women with sexual dysfunction, mood disorders, fibroids and urogenital complaints, as well as those with breast tenderness or high mammographic breast density with EPT use [6].
  • Vasectomized copulations protect against fibroids, an observation that undermines the steroid hypothesis and supports our hypothesis [7].

High impact information on Leiomyoma


Chemical compound and disease context of Leiomyoma


Biological context of Leiomyoma


Anatomical context of Leiomyoma


Gene context of Leiomyoma

  • Concomitantly, HMGA2 protein, which was completely absent in normal myometria, was expressed in 16 of 19 Eker leiomyomas [14].
  • HMGA1 was expressed in both leiomyoma and normal myometria [14].
  • Eker leiomyomas exhibited a 50% incidence of loss of the wild-type Tsc2 allele and an almost uniform loss of protein expression, implicating loss of function of the Tsc2 gene in these tumors [14].
  • We demonstrate here the occurrence of a somatic deletion at the COL4A5/COL4A6 locus at Xq22 in a frozen leiomyoma sample [19].
  • In addition, not only leiomyosarcoma, but also leiomyoma specimens that exhibited negligible levels of complex expression, manifested detectable cdk2 activity [22].

Analytical, diagnostic and therapeutic context of Leiomyoma


  1. Selective progesterone receptor modulator development and use in the treatment of leiomyomata and endometriosis. Chwalisz, K., Perez, M.C., Demanno, D., Winkel, C., Schubert, G., Elger, W. Endocr. Rev. (2005) [Pubmed]
  2. Regulation of aromatase expression in estrogen-responsive breast and uterine disease: from bench to treatment. Bulun, S.E., Lin, Z., Imir, G., Amin, S., Demura, M., Yilmaz, B., Martin, R., Utsunomiya, H., Thung, S., Gurates, B., Tamura, M., Langoi, D., Deb, S. Pharmacol. Rev. (2005) [Pubmed]
  3. Expression of insulin-like growth factor-I and -II genes in human smooth muscle tumours. Höppener, J.W., Mosselman, S., Roholl, P.J., Lambrechts, C., Slebos, R.J., de Pagter-Holthuizen, P., Lips, C.J., Jansz, H.S., Sussenbach, J.S. EMBO J. (1988) [Pubmed]
  4. Accumulation of Krebs cycle intermediates and over-expression of HIF1alpha in tumours which result from germline FH and SDH mutations. Pollard, P.J., Brière, J.J., Alam, N.A., Barwell, J., Barclay, E., Wortham, N.C., Hunt, T., Mitchell, M., Olpin, S., Moat, S.J., Hargreaves, I.P., Heales, S.J., Chung, Y.L., Griffiths, J.R., Dalgleish, A., McGrath, J.A., Gleeson, M.J., Hodgson, S.V., Poulsom, R., Rustin, P., Tomlinson, I.P. Hum. Mol. Genet. (2005) [Pubmed]
  5. Few FH mutations in sporadic counterparts of tumor types observed in hereditary leiomyomatosis and renal cell cancer families. Kiuru, M., Lehtonen, R., Arola, J., Salovaara, R., Järvinen, H., Aittomäki, K., Sjöberg, J., Visakorpi, T., Knuutila, S., Isola, J., Delahunt, B., Herva, R., Launonen, V., Karhu, A., Aaltonen, L.A. Cancer Res. (2002) [Pubmed]
  6. Tibolone: clinical recommendations and practical guidelines. A report of the International Tibolone Consensus Group. Kenemans, P., Speroff, L. Maturitas. (2005) [Pubmed]
  7. Sympathetic and T helper (Th)2 bias may ameliorate uterine fibroids, independent of sex steroids. Yun, A.J., Daniel, S.M. Med. Hypotheses (2005) [Pubmed]
  8. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Tomlinson, I.P., Alam, N.A., Rowan, A.J., Barclay, E., Jaeger, E.E., Kelsell, D., Leigh, I., Gorman, P., Lamlum, H., Rahman, S., Roylance, R.R., Olpin, S., Bevan, S., Barker, K., Hearle, N., Houlston, R.S., Kiuru, M., Lehtonen, R., Karhu, A., Vilkki, S., Laiho, P., Eklund, C., Vierimaa, O., Aittomäki, K., Hietala, M., Sistonen, P., Paetau, A., Salovaara, R., Herva, R., Launonen, V., Aaltonen, L.A. Nat. Genet. (2002) [Pubmed]
  9. Estradiol-dependent uterine leiomyomas in transgenic mice. Romagnolo, B., Molina, T., Leroy, G., Blin, C., Porteux, A., Thomasset, M., Vandewalle, A., Kahn, A., Perret, C. J. Clin. Invest. (1996) [Pubmed]
  10. Purification and partial sequencing of the major mitogen for human uterine smooth muscle-like cells in leiomyoma extracts. Sourla, A., Koutsilieris, M. J. Clin. Invest. (1995) [Pubmed]
  11. Goserelin therapy before surgery for uterine fibroids. Lumsden, M.A., West, C.P., Baird, D.T. Lancet (1987) [Pubmed]
  12. Presence of an insulin-like growth factor I autocrine loop predicts uterine fibroid responsiveness to tamoxifen. Howe, S.R., Pass, H.I., Ethier, S.P., Matthews, W.J., Walker, C. Cancer Res. (1996) [Pubmed]
  13. Isolation and characterization of proteoglycans from human nonepithelial tumors. Sobue, M., Takeuchi, J., Yoshida, K., Akao, S., Fukatsu, T., Nagasaka, T., Nakashima, N. Cancer Res. (1987) [Pubmed]
  14. Aberrant expression of HMGA2 in uterine leiomyoma associated with loss of TSC2 tumor suppressor gene function. Hunter, D.S., Klotzbücher, M., Kugoh, H., Cai, S.L., Mullen, J.P., Manfioletti, G., Fuhrman, U., Walker, C.L. Cancer Res. (2002) [Pubmed]
  15. Heparin inhibits the motility and proliferation of human myometrial and leiomyoma smooth muscle cells. Mason, H.R., Nowak, R.A., Morton, C.C., Castellot, J.J. Am. J. Pathol. (2003) [Pubmed]
  16. Distinct expression profile in fumarate-hydratase-deficient uterine fibroids. Vanharanta, S., Pollard, P.J., Lehtonen, H.J., Laiho, P., Sjöberg, J., Leminen, A., Aittomäki, K., Arola, J., Kruhoffer, M., Orntoft, T.F., Tomlinson, I.P., Kiuru, M., Arango, D., Aaltonen, L.A. Hum. Mol. Genet. (2006) [Pubmed]
  17. Loss of heterozygosity and reduced expression of the CUTL1 gene in uterine leiomyomas. Zeng, W.R., Scherer, S.W., Koutsilieris, M., Huizenga, J.J., Filteau, F., Tsui, L.C., Nepveu, A. Oncogene (1997) [Pubmed]
  18. Plasminogen activator inhibitor 1 messenger RNA expression and molecular evidence for del(7)(q22) in uterine leiomyomas. Sourla, A., Polychronakos, C., Zeng, W.R., Nepveu, A., Kukuvitis, A., Naud, F., Koutsilieris, M. Cancer Res. (1996) [Pubmed]
  19. Somatic deletion of the 5' ends of both the COL4A5 and COL4A6 genes in a sporadic leiomyoma of the esophagus. Heidet, L., Boye, E., Cai, Y., Sado, Y., Zhang, X., Fléjou, J.F., Fékété, F., Ninomiya, Y., Gubler, M.C., Antignac, C. Am. J. Pathol. (1998) [Pubmed]
  20. HMGI-C rearrangements as the molecular basis for the majority of pulmonary chondroid hamartomas: a survey of 30 tumors. Kazmierczak, B., Rosigkeit, J., Wanschura, S., Meyer-Bolte, K., Van de Ven, W.J., Kayser, K., Krieghoff, B., Kastendiek, H., Bartnitzke, S., Bullerdiek, J. Oncogene (1996) [Pubmed]
  21. Increased expression of Bcl-2 protein in human uterine leiomyoma and its up-regulation by progesterone. Matsuo, H., Maruo, T., Samoto, T. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  22. Involvement of cyclins in cell proliferation and their clinical implications in soft tissue smooth muscle tumors. Noguchi, T., Dobashi, Y., Minehara, H., Itoman, M., Kameya, T. Am. J. Pathol. (2000) [Pubmed]
  23. Messenger ribonucleic acid expression of the insulin-like growth factors and their binding proteins in uterine fibroids and myometrium. Vollenhoven, B.J., Herington, A.C., Healy, D.L. J. Clin. Endocrinol. Metab. (1993) [Pubmed]
  24. Comparative messenger ribonucleic acid analysis of immediate early genes and sex steroid receptors in human leiomyoma and healthy myometrium. Lessl, M., Klotzbuecher, M., Schoen, S., Reles, A., Stöckemann, K., Fuhrmann, U. J. Clin. Endocrinol. Metab. (1997) [Pubmed]
  25. p53 Tumor suppressor protein content in human uterine leiomyomas and its down-regulation by 17 beta-estradiol. Gao, Z., Matsuo, H., Nakago, S., Kurachi, O., Maruo, T. J. Clin. Endocrinol. Metab. (2002) [Pubmed]
  26. p53 immunoreactivity and mutation of the p53 gene in smooth muscle tumours of the uterine corpus. Jeffers, M.D., Farquharson, M.A., Richmond, J.A., McNicol, A.M. J. Pathol. (1995) [Pubmed]
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