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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
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Disease relevance of Neurilemmoma


High impact information on Neurilemmoma


Chemical compound and disease context of Neurilemmoma

  • Sequential development of ethylnitrosourea-induced neurinomas: morphology, biochemistry, and transplantability [10].
  • Effect of levamisole on malignant experimental neurinoma grown subcutaneously in a young rat: brief communication [11].
  • Polyacrylamide gels of antilaminin immunoprecipitates of conditioned medium and solubilized Schwannoma cells contained bands of reduced Mr 200,000 and 150,000 [12].
  • We show enhanced adhesion in primary human schwannoma cells and present evidence that this is dependent on the integrin chains alpha6beta1 and alpha6beta4 [13].
  • Rat RN22 schwannoma cells in vitro release into their growth medium a macromolecular factor that, when bound to polyornithine-coated culture substrata, will stimulate neuritic regeneration from axotomized peripheral and central neurons [14].

Biological context of Neurilemmoma


Anatomical context of Neurilemmoma


Gene context of Neurilemmoma

  • We demonstrate that regulated overexpression of HRS in rat schwannoma cells results in similar effects as overexpression of merlin, including growth inhibition, decreased motility and abnormalities in cell spreading [25].
  • Prkar1a(+/-) mice developed nonpigmented schwannomas and fibro-osseous bone lesions beginning at approximately 6 months of age [24].
  • In contrast, PCNA is more highly expressed in cellular schwannomas [26].
  • Neuregulin growth factors and their ErbB receptors form a potential signaling network for schwannoma tumorigenesis [27].
  • Rearrangements of the intermediate filament GFAP in primary human schwannoma cells [28].

Analytical, diagnostic and therapeutic context of Neurilemmoma


  1. Mutations of the gene encoding the protein kinase A type I-alpha regulatory subunit in patients with the Carney complex. Kirschner, L.S., Carney, J.A., Pack, S.D., Taymans, S.E., Giatzakis, C., Cho, Y.S., Cho-Chung, Y.S., Stratakis, C.A. Nat. Genet. (2000) [Pubmed]
  2. The involvement of calpain-dependent proteolysis of the tumor suppressor NF2 (merlin) in schwannomas and meningiomas. Kimura, Y., Koga, H., Araki, N., Mugita, N., Fujita, N., Takeshima, H., Nishi, T., Yamashima, T., Saido, T.C., Yamasaki, T., Moritake, K., Saya, H., Nakao, M. Nat. Med. (1998) [Pubmed]
  3. GFA and S 100 protein levels as an index for malignancy in human gliomas and neurinomas. Jacque, C.M., Kujas, M., Poreau, A., Raoul, M., Collier, P., Racadot, J., Baumann, N. J. Natl. Cancer Inst. (1979) [Pubmed]
  4. Sequential adsorption analysis of antibodies to neuroectodermal cells by an indirect quantitative method. Harwood, S.E., Bigner, D.D., Wechsler, W., Day, E.D. J. Natl. Cancer Inst. (1976) [Pubmed]
  5. MDM2 gene amplification and transcript levels in human sarcomas: relationship to TP53 gene status. Flørenes, V.A., Maelandsmo, G.M., Forus, A., Andreassen, A., Myklebost, O., Fodstad, O. J. Natl. Cancer Inst. (1994) [Pubmed]
  6. Paxillin binds schwannomin and regulates its density-dependent localization and effect on cell morphology. Fernandez-Valle, C., Tang, Y., Ricard, J., Rodenas-Ruano, A., Taylor, A., Hackler, E., Biggerstaff, J., Iacovelli, J. Nat. Genet. (2002) [Pubmed]
  7. Adenosine 3',5'-monophosphate analogs promote a circular morphology of cultured Schwannoma cells. Sheppard, J.R., Hudson, T.H., Larson, J.R. Science (1975) [Pubmed]
  8. Neurogenic tumors in coho salmon (Oncorhynchus kisutch) reared in well water in Japan. Masahito, P., Ishikawa, T., Yanagisawa, A., Sugano, H., Ikeda, K. J. Natl. Cancer Inst. (1985) [Pubmed]
  9. Genetics of susceptibility of rats to trigeminal schwannomas induced by neonatal administration of N-ethyl-N-nitrosourea. Naito, M., Ito, A., Aoyama, H. J. Natl. Cancer Inst. (1985) [Pubmed]
  10. Sequential development of ethylnitrosourea-induced neurinomas: morphology, biochemistry, and transplantability. Swenberg, J.A., Clendenon, N., Denlinger, R., Gordon, W.A. J. Natl. Cancer Inst. (1975) [Pubmed]
  11. Effect of levamisole on malignant experimental neurinoma grown subcutaneously in a young rat: brief communication. Aleksic, S., Drnovski, F., Bloom, A., Rappaport, H., Ransohoff, J. J. Natl. Cancer Inst. (1977) [Pubmed]
  12. Production of laminin and fibronectin by Schwannoma cells: cell-protein interactions in vitro and protein localization in peripheral nerve in vivo. Palm, S.L., Furcht, L.T. J. Cell Biol. (1983) [Pubmed]
  13. Pathological adhesion of primary human schwannoma cells is dependent on altered expression of integrins. Utermark, T., Kaempchen, K., Hanemann, C.O. Brain Pathol. (2003) [Pubmed]
  14. Isolation and characterization of rat schwannoma neurite-promoting factor: evidence that the factor contains laminin. Davis, G.E., Manthorpe, M., Engvall, E., Varon, S. J. Neurosci. (1985) [Pubmed]
  15. Schwann cell hyperplasia and tumors in transgenic mice expressing a naturally occurring mutant NF2 protein. Giovannini, M., Robanus-Maandag, E., Niwa-Kawakita, M., van der Valk, M., Woodruff, J.M., Goutebroze, L., Mérel, P., Berns, A., Thomas, G. Genes Dev. (1999) [Pubmed]
  16. Molecular analysis of the NF2 tumor-suppressor gene in schwannomatosis. Jacoby, L.B., Jones, D., Davis, K., Kronn, D., Short, M.P., Gusella, J., MacCollin, M. Am. J. Hum. Genet. (1997) [Pubmed]
  17. Upregulation of the Rac1/JNK signaling pathway in primary human schwannoma cells. Kaempchen, K., Mielke, K., Utermark, T., Langmesser, S., Hanemann, C.O. Hum. Mol. Genet. (2003) [Pubmed]
  18. Neurofibromatosis 2 (NF2) tumor suppressor schwannomin and its interacting protein HRS regulate STAT signaling. Scoles, D.R., Nguyen, V.D., Qin, Y., Sun, C.X., Morrison, H., Gutmann, D.H., Pulst, S.M. Hum. Mol. Genet. (2002) [Pubmed]
  19. Exon scanning for mutation of the NF2 gene in schwannomas. Jacoby, L.B., MacCollin, M., Louis, D.N., Mohney, T., Rubio, M.P., Pulaski, K., Trofatter, J.A., Kley, N., Seizinger, B., Ramesh, V. Hum. Mol. Genet. (1994) [Pubmed]
  20. Abnormal regulation of mammalian p21ras contributes to malignant tumor growth in von Recklinghausen (type 1) neurofibromatosis. DeClue, J.E., Papageorge, A.G., Fletcher, J.A., Diehl, S.R., Ratner, N., Vass, W.C., Lowy, D.R. Cell (1992) [Pubmed]
  21. beta-Nerve growth factor (beta NGF) receptors on glial cells. Cell-cell interaction between neurones and Schwann cells in cultures of chick sensory ganglia. Zimmermann, A., Sutter, A. EMBO J. (1983) [Pubmed]
  22. Schwannoma-derived growth factor promotes the neuronal differentiation and survival of PC12 cells. Kimura, H., Schubert, D. J. Cell Biol. (1992) [Pubmed]
  23. Nuclear/growth factors. Prochiantz, A., Théodore, L. Bioessays (1995) [Pubmed]
  24. A mouse model for the Carney complex tumor syndrome develops neoplasia in cyclic AMP-responsive tissues. Kirschner, L.S., Kusewitt, D.F., Matyakhina, L., Towns, W.H., Carney, J.A., Westphal, H., Stratakis, C.A. Cancer Res. (2005) [Pubmed]
  25. The NF2 interactor, hepatocyte growth factor-regulated tyrosine kinase substrate (HRS), associates with merlin in the "open" conformation and suppresses cell growth and motility. Gutmann, D.H., Haipek, C.A., Burke, S.P., Sun, C.X., Scoles, D.R., Pulst, S.M. Hum. Mol. Genet. (2001) [Pubmed]
  26. Cellular schwannomas of the intracranial and intraspinal compartment: morphological and immunological characteristics compared with classical benign schwannomas. Deruaz, J.P., Janzer, R.C., Costa, J. J. Neuropathol. Exp. Neurol. (1993) [Pubmed]
  27. Neuregulin growth factors and their ErbB receptors form a potential signaling network for schwannoma tumorigenesis. Stonecypher, M.S., Chaudhury, A.R., Byer, S.J., Carroll, S.L. J. Neuropathol. Exp. Neurol. (2006) [Pubmed]
  28. Rearrangements of the intermediate filament GFAP in primary human schwannoma cells. Utermark, T., Schubert, S.J., Hanemann, C.O. Neurobiol. Dis. (2005) [Pubmed]
  29. Universal absence of merlin, but not other ERM family members, in schwannomas. Stemmer-Rachamimov, A.O., Xu, L., Gonzalez-Agosti, C., Burwick, J.A., Pinney, D., Beauchamp, R., Jacoby, L.B., Gusella, J.F., Ramesh, V., Louis, D.N. Am. J. Pathol. (1997) [Pubmed]
  30. Treatment of schwannomas with an oncolytic recombinant herpes simplex virus in murine models of neurofibromatosis type 2. Messerli, S.M., Prabhakar, S., Tang, Y., Mahmood, U., Weissleder, R., Bronson, R., Martuza, R., Rabkin, S., Breakefield, X.O. Hum. Gene Ther. (2006) [Pubmed]
  31. Apolipoprotein E synthesis in neurofibrosarcoma and schwannoma cell cultures from two individuals with neurofibromatosis. Gebicke-Haerter, P.J., Darby, J.K., Shooter, E.M., Riccardi, V.M., Weisgraber, K.H., Boyles, J.K., Mahley, R.W. Exp. Neurol. (1987) [Pubmed]
  32. Tissue-specific expression and methylation of the human CYP2E1 gene. Botto, F., Seree, E., el Khyari, S., de Sousa, G., Massacrier, A., Placidi, M., Cau, P., Pellet, W., Rahmani, R., Barra, Y. Biochem. Pharmacol. (1994) [Pubmed]
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