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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

dazl  -  deleted in azoospermia-like

Danio rerio

Synonyms: DAZ-like protein, Deleted in azoospermia-like, SO:0000704, zDazl, zdazl
 
 
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High impact information on dazl

  • We also found novel localization patterns for zDazl and brul mRNAs along the cleavage planes [1].
  • Here we report that the germ plasm RNAs vasa, nanos1, and dazl co-localize with the mitochondrial cloud (MC) and are transported to the vegetal cortex during early oogenesis [2].
  • The germ plasm includes maternal mRNAs from the germline-specific genes such as vasa and nanos1, and vegetally localized dazl RNA is also incorporated into the germ plasm [2].
  • RESULTS: Using in vitro selection and UV-crosslinking experiments, we identified the sequence 'GUUC' as the target RNA sequence of zebrafish DAZ-like protein (zDAZL) [3].
  • In transfection experiments, zDAZL protein activated translation in a manner dependent on the binding sequence in the 3'UTR of the Drosophila twine gene or zDazl gene [3].
 

Biological context of dazl

 

Anatomical context of dazl

References

  1. Localized maternal factors are required for zebrafish germ cell formation. Hashimoto, Y., Maegawa, S., Nagai, T., Yamaha, E., Suzuki, H., Yasuda, K., Inoue, K. Dev. Biol. (2004) [Pubmed]
  2. Spatiotemporal localization of germ plasm RNAs during zebrafish oogenesis. Kosaka, K., Kawakami, K., Sakamoto, H., Inoue, K. Mech. Dev. (2007) [Pubmed]
  3. Zebrafish DAZ-like protein controls translation via the sequence 'GUUC'. Maegawa, S., Yamashita, M., Yasuda, K., Inoue, K. Genes Cells (2002) [Pubmed]
  4. Maternal mRNA localization of zebrafish DAZ-like gene. Maegawa, S., Yasuda, K., Inoue, K. Mech. Dev. (1999) [Pubmed]
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