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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Gene Review: 

DAZ2  -  deleted in azoospermia 2

Homo sapiens

Synonyms: Deleted in azoospermia protein 2, MGC126442, pDP1678
 
 
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High impact information on DAZ2

  • Furthermore, the DAZ1/DAZ2 deletion has been detected as the primary subtype of the gr/gr deletion in East Asians, though this doublet has been considered as crucial for normal spermatogenesis in Europeans [1].
  • Differences between incomplete (23.3%) and complete (4.5%) MA cases regarding AZFc and DAZ1/DAZ2 deletion frequencies, and between incomplete (58.3%) and complete (11.1%) SCOS cases for AZFc deletions, suggest that incomplete syndromes might represent an aggravation of the oligozoospermic phenotype [2].
  • High frequency of DAZ1/DAZ2 gene deletions in patients with severe oligozoospermia [3].
  • Immunostaining experiments with antibodies prepared for the specific peptide domain encoded by the DAZ2 transcript (formerly SPGY1) revealed the presence of DAZ proteins in the innermost layer of the male germ cell epithelium and in the tails of spermatozoa [4].
  • Since SFV showed clearly the presence of DAZ2, it may be hypothesized that C5 lacks DAZ4 [5].
 

Biological context of DAZ2

  • DAZ1/DAZ2 cluster deletion mediated by gr/gr recombination per se may not be sufficient for spermatogenesis impairment: a study of Chinese normozoospermic men [6].
 

Other interactions of DAZ2

  • The loss of two signals in this subject may relate to a deletion of both DAZ2 and DAZ3 or of DAZ4 gene [5].
 

Analytical, diagnostic and therapeutic context of DAZ2

  • We therefore conclude that the deletion of the DAZ1/DAZ2 gene doublet in five out of our 63 oligozoospermic patients (8%) is responsible for the patients' reduced sperm numbers [3].

References

  1. A frequent partial AZFc deletion does not render an increased risk of spermatogenic impairment in East Asians. Zhang, F., Li, Z., Wen, B., Jiang, J., Shao, M., Zhao, Y., He, Y., Song, X., Qian, J., Lu, D., Jin, L. Ann. Hum. Genet. (2006) [Pubmed]
  2. AZF and DAZ gene copy-specific deletion analysis in maturation arrest and Sertoli cell-only syndrome. Ferrás, C., Fernandes, S., Marques, C.J., Carvalho, F., Alves, C., Silva, J., Sousa, M., Barros, A. Mol. Hum. Reprod. (2004) [Pubmed]
  3. High frequency of DAZ1/DAZ2 gene deletions in patients with severe oligozoospermia. Fernandes, S., Huellen, K., Goncalves, J., Dukal, H., Zeisler, J., Rajpert De Meyts, E., Skakkebaek, N.E., Habermann, B., Krause, W., Sousa, M., Barros, A., Vogt, P.H. Mol. Hum. Reprod. (2002) [Pubmed]
  4. DAZ (Deleted in AZoospermia) genes encode proteins located in human late spermatids and in sperm tails. Habermann, B., Mi, H.F., Edelmann, A., Bohring, C., Bäckert, I.T., Kiesewetter, F., Aumüller, G., Vogt, P.H. Hum. Reprod. (1998) [Pubmed]
  5. Quantitative evaluation of partial deletions of the DAZ gene cluster. D'Amico, G.L., Di Benedetto, D., Pezzino, F.M., Giuffrida, V., Libra, M., Fichera, M., Mauceri, G., Rappazzo, G., D'Agata, R., Vicari, E., Travali, S., Calogero, A.E. Int. J. Mol. Med. (2006) [Pubmed]
  6. DAZ1/DAZ2 cluster deletion mediated by gr/gr recombination per se may not be sufficient for spermatogenesis impairment: a study of Chinese normozoospermic men. Yang, Y., Xiao, C.Y., A, Z.C., Zhang, S.Z., Li, X., Zhang, S.X. Asian J. Androl. (2006) [Pubmed]
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