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Gene Review:

valopa - vertebrate ancient long opsin a

Danio rerio

Synonyms: (VA)-opsin, SO:0000704, VA-opsin, VAL-opsin, valop

Kojima, D. et al., Minamoto, T. et al., Kojima, D. et al.

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High impact information on valop

Vertebrate ancient-long opsin: a green-sensitive photoreceptive molecule present in zebrafish deep brain and retinal horizontal cells [1].
Functional reconstitution experiments on the recombinant proteins showed that VAL-opsin with bound 11-cis-retinal is a green-sensitive pigment (lambdamax approximately 500 nm), whereas VA-opsin exhibited no photosensitivity even in the presence of 11-cis-retinal [1].
Immunoreactivity specific to this functionally active VAL-opsin was localized at a limited number of cells surrounding the diencephalic ventricle of central thalamus, and these cells were distributed over approximately 200 micrometer along the rostrocaudal axis [1].

Anatomical context of valop

We also identified VAL opsin in zebrafish retinal horizontal cells, which have not been considered as photoreceptive cells [2].

Analytical, diagnostic and therapeutic context of valop

Southern blotting experiments indicated that the VA opsin gene of the smelt is present as a single copy, and RT-PCR analysis revealed that Pal-VAM and Pal-VAL mRNA were expressed in both the eyes and brain [3].

References

Vertebrate ancient-long opsin: a green-sensitive photoreceptive molecule present in zebrafish deep brain and retinal horizontal cells. Kojima, D., Mano, H., Fukada, Y. J. Neurosci. (2000) [Pubmed]
Non-visual photoreception by a variety of vertebrate opsins. Kojima, D., Fukada, Y. Novartis Found. Symp. (1999) [Pubmed]
A novel isoform of vertebrate ancient opsin in a smelt fish, Plecoglossus altivelis. Minamoto, T., Shimizu, I. Biochem. Biophys. Res. Commun. (2002) [Pubmed]

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valopb	Danio rerio
OPNVA	Gallus gallus
LOC100489056	Xenopus (Silurana) tropicalis

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